Cloned (Comment) | Organism |
---|---|
full-length lipin1beta cDNA amplified and cloned into the pcDNA3.1-V5/His-TOPO expression vector and pSG5-FLAG-tagged expression vector. Peroxisome proliferator-activated receptor gamma2 and lipin1 overexpressed in NIH3T3 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of IL728FF does not affect the interaction with peroxisome proliferator-activated receptor gamma2 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
preadipocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
lipin1alpha | - |
Mus musculus |
lipin1beta | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | lipin1 is induced in the late stages of adipocyte differentiation. During the maturation of adipocytes, the increase of lipin1alpha is less than that of lipin1beta. CCAAT/enhancer-binding protein alpha directly controls the expression of lipin1, overexpression of CCAAT/enhancer-binding protein alpha activates the lipin1 promoter (from nt -1340 to -524) about 6fold over the basal activity in a transient transfection assay | up |
General Information | Comment | Organism |
---|---|---|
physiological function | lipin1 reinforces the positive feedback loop between CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma2, which is essential for adipogenesis and the maintenance of adipocyte functions. Lipin1 is necessary and accelerates 3T3-L1 adipocyte differentiation. Lipin1 maintains the expression of adipocyte functional genes in 3T3-L1 mature adipocytes. Lipin1 functions by interacting with and activating peroxisome proliferator-activated receptor gamma2 | Homo sapiens |