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Literature summary for 3.1.3.4 extracted from

  • Pyne, S.; Lee, S.C.; Long, J.; Pyne, N.J.
    Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease (2009), Cell. Signal., 21, 14-21.
    View publication on PubMed
Search for more literature for 3.1.3.4

Activating Compound

Activating Compound Comment Organism Structure
additional information is N-ethylmaleimide insensitive Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
LPP1, LPP2 and LPP3 Homo sapiens

Protein Variants

Protein Variants Comment Organism
R127K/H223L negligible LPP1 activity, although each mutant is still able to form oligomers Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane LPPs are integral membrane proteins with six transmembrane domains Homo sapiens 16020
-
additional information LPP1 and LPP3 are present in caveolae, localised to distinct lipid rafts Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information is Mg2+ independent Homo sapiens

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Drosophila melanogaster
-
embryonic fibroblast
-
 Mus musculus
-
posterior midgut
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide 1-phosphate + H2O
-
 Homo sapiens ceramide + phosphate
-
 ?
lysophosphatidic acid + H2O
-
 Homo sapiens monoacylglycerol + phosphate
-
 ?
additional information the catalytic site is arranged into three distinct domains: one substrate recognition site and two catalytic sites Homo sapiens ?
-
 ?
phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?
sphingosine 1-phosphate + H2O
-
 Homo sapiens sphingosine + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer catalytic activity is required for dimerisation Drosophila melanogaster
hexamer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
-
 Drosophila melanogaster
lipid phosphate phosphatase
-
 Mus musculus
lipid phosphate phosphatase
-
 Homo sapiens
LPP1
-
 Mus musculus
LPP1
-
 Homo sapiens
LPP2
-
 Homo sapiens
LPP3
-
 Homo sapiens
Wunen
-
 Drosophila melanogaster
wunen-2
-
 Drosophila melanogaster

Expression

Organism Comment Expression
Homo sapiens epidermal growth factor increases LPP3 mRNA in HeLa cells. Androgen increases LPP1 mRNA in adenocarcinoma cells up

General Information

General Information Comment Organism
physiological function physiologically relevant increases in LPP1 activity in mouse embryonic fibroblasts (isolated from transgenic mice with 20 gene copies of LPP1) reduces lysophosphatidic acid- and platelet-derived growth factor-activation of ERK-1/2 and migration, resulting from down-regulation of typical proteinkinase C isoform(s) which are required for regulation of cell migration Mus musculus
physiological function stable overexpression of LPP1 or LPP2 reduces sphingosine 1-phosphate, lysophosphatidic acid- and thrombin-induced activation of ERK-1/2 Homo sapiens
physiological function wunen generates a phospholipid gradient and thereby repels germ cells towards higher phospholipid levels and away from the midline. Wunen/wunen-2 also governs the death of mis-migrating germ cells and survival of pole cells which compete for a common phospholipid substrate with somatic cells Drosophila melanogaster