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Literature summary for 3.1.3.4 extracted from
- The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL (2009), J. Lipid Res., 50, 47-58.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient expression of lipin-1 in McA-RH7777 cells specifically influences the rate of incorporation of methionine into apolipoprotein B100, and stimulates its synthesis and secretion, overview | Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | lipin-1 siRNA treatment of cells reduces the expression level of lipin-1, overview | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
| additional information | the NLS sequences govern nuclear localization of lipin-1alpha and determine its membrane association and physiological function | Rattus norvegicus | - |
- |
| nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | expression of lipin-1 cells stimulates glycerolipid synthesis and secretion in McA-RH7777, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | primary | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | expression of lipin-1 cells stimulates glycerolipid synthesis and secretion in McA-RH7777, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipin-1 | - |
Rattus norvegicus |
| PAP-1 | - |
Rattus norvegicus |
| phosphatidate phosphatase-1 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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