Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.4 extracted from

  • Reue, K.; Brindley, D.N.
    Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism (2008), J. Lipid Res., 49, 2493-2503.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene LPIN2 is located on chromosome 18p11 Homo sapiens
genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes Mus musculus
genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information lipin-1-deficient fld mice show that lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle, targeted expression of lipin-1 in adipose tissue of transgenic mice leads to obesity, overview Mus musculus
additional information mutations of lipin-1 cause recurrent acute myoglobinuria, lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide
-
Homo sapiens
N-ethylmaleimide
-
Mus musculus
N-ethylmaleimide
-
Rattus norvegicus
N-ethylmaleimide
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Saccharomyces cerevisiae 5829
-
endoplasmic reticulum the enzyme binds to the cytosolic side of the membranes, overview Mus musculus 5783
-
endoplasmic reticulum the enzyme binds to the cytosolic side of the membranes, overview Homo sapiens 5783
-
endoplasmic reticulum the enzyme binds to the cytosolic side of the membranes, overview Rattus norvegicus 5783
-
membrane bound to microsomal and plasma membranes Mus musculus 16020
-
membrane bound to microsomal and plasma membranes Homo sapiens 16020
-
membrane bound to microsomal and plasma membranes Rattus norvegicus 16020
-
nucleus lipin-1 Mus musculus 5634
-
nucleus lipin-1 Homo sapiens 5634
-
nucleus lipin-1 Rattus norvegicus 5634
-
nucleus Pah1p Saccharomyces cerevisiae 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ required Homo sapiens
Mg2+ required Rattus norvegicus
Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3-sn-phosphatidate + H2O Mus musculus key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O Homo sapiens key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O Rattus norvegicus key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O Saccharomyces cerevisiae key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview a 1,2-diacyl-sn-glycerol + phosphate
-
?
additional information Homo sapiens lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria ?
-
?
additional information Saccharomyces cerevisiae lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism ?
-
?
additional information Mus musculus lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism ?
-
?
additional information Rattus norvegicus lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation play an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine Homo sapiens
phosphoprotein phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 and lipin-2 is associated with reduced PAP1 activity druing mitosis, phosphorylation of lipin-1, mainly at Ser106, influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine Mus musculus
phosphoprotein phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine Rattus norvegicus
phosphoprotein phosphorylation, e.g. by Nem1p, plays an important role in modulation of enzyme activity, overview Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle Mus musculus
-
adipose tissue lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle Homo sapiens
-
adipose tissue lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle Rattus norvegicus
-
liver expression of both splicing variants of lipin-1 Mus musculus
-
liver expression of both splicing variants of lipin-1 Rattus norvegicus
-
additional information tissue-dependent regulation of PAP1, overview Mus musculus
-
additional information tissue-dependent regulation of PAP1, overview Homo sapiens
-
additional information tissue-dependent regulation of PAP1, overview Rattus norvegicus
-
skeletal muscle lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle Mus musculus
-
skeletal muscle lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle Homo sapiens
-
skeletal muscle lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 3-sn-phosphatidate + H2O
-
Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O
-
Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O
-
Rattus norvegicus a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O
-
Saccharomyces cerevisiae a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview Rattus norvegicus a 1,2-diacyl-sn-glycerol + phosphate
-
?
a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview Saccharomyces cerevisiae a 1,2-diacyl-sn-glycerol + phosphate
-
?
additional information lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria Homo sapiens ?
-
?
additional information lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism Saccharomyces cerevisiae ?
-
?
additional information lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism Mus musculus ?
-
?
additional information lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism Rattus norvegicus ?
-
?
additional information PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
More PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
lipin-1
-
Mus musculus
lipin-1
-
Homo sapiens
lipin-1
-
Rattus norvegicus
lipin-1
-
Saccharomyces cerevisiae
lipin-2
-
Mus musculus
lipin-2
-
Homo sapiens
lipin-2
-
Rattus norvegicus
lipin-2
-
Saccharomyces cerevisiae
lipin-3
-
Mus musculus
lipin-3
-
Homo sapiens
lipin-3
-
Rattus norvegicus
lipin-3
-
Saccharomyces cerevisiae
More the enzyme belongs to the lipin family Mus musculus
More the enzyme belongs to the lipin family Homo sapiens
More the enzyme belongs to the lipin family Rattus norvegicus
More the enzyme belongs to the lipin family Saccharomyces cerevisiae
Pah1p
-
Saccharomyces cerevisiae
PAP-1
-
Homo sapiens
PAP1
-
Mus musculus
PAP1
-
Rattus norvegicus
PAP1
-
Saccharomyces cerevisiae
phosphatidate phosphatase-1
-
Mus musculus
phosphatidate phosphatase-1
-
Homo sapiens
phosphatidate phosphatase-1
-
Rattus norvegicus
phosphatidate phosphatase-1
-
Saccharomyces cerevisiae