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Literature summary for 3.1.3.4 extracted from

  • Ryu, D.; Oh, K.J.; Jo, H.Y.; Hedrick, S.; Kim, Y.N.; Hwang, Y.J.; Park, T.S.; Han, J.S.; Choi, C.S.; Montminy, M.; Koo, S.H.
    TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1 (2009), Cell Metab., 9, 240-251.
    View publication on PubMed
Search for more literature for 3.1.3.4

Activating Compound

Activating Compound Comment Organism Structure
additional information hyperactivated TORC2 enhances expression of lipin1. Diet-induced or genetic obesity increases LIPIN1 expression in mouse liver, and TORC2 is responsible for its transcriptional activation Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of LIPIN1 disturbs hepatic insulin signaling, knockdown of LIPIN1 ameliorates hyperglycemia and insulin resistance by reducing diacylglycerol and PKC3 activity in db/db mice. TORC2-mediated insulin resistance is partially rescued by concomitant knockdown of LIPIN1, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3-sn-phosphatidate + H2O Mus musculus lipin-1 plays a critical role in the perturbation of hepatic insulin signaling a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
additional information Mus musculus hyperactivation of TORC2 exacerbates insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol synthesis, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene LIPIN1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 3-sn-phosphatidate + H2O
-
 Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
a 3-sn-phosphatidate + H2O lipin-1 plays a critical role in the perturbation of hepatic insulin signaling Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
additional information hyperactivation of TORC2 exacerbates insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol synthesis, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
lipin-1
-
 Mus musculus
phosphatidic acid phosphatase
-
 Mus musculus