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Literature summary for 3.1.3.4 extracted from

  • Grkovich, A.; Armando, A.; Quehenberger, O.; Dennis, E.A.
    TLR-4 mediated group IVA phospholipase A2 activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent (2009), Biochim. Biophys. Acta, 1791, 975-982.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.4

Protein Variants

Protein Variants Comment Organism
additional information PAP-1 inhibition leads to the loss of cyclooxygenase 2 expression and PGE2 release Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
bromoenol lactone
-
 Mus musculus
additional information PAP-1 chemical inhibition does not reduce the synergistic activation of group IVA phospholipase A2 Mus musculus
propranolol
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3-sn-phosphatidate + H2O Mus musculus
-
 a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
additional information Mus musculus phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 3-sn-phosphatidate + H2O
-
 Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
additional information phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PAP-1
-
 Mus musculus
phosphatidic acid phosphohydrolase 1
-
 Mus musculus