Literature summary for 3.1.3.4 extracted from

Theofilopoulos, S.; Lykidis, A.; Leondaritis, G.; Mangoura, D.
Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways (2008), Biochim. Biophys. Acta, 1781, 731-742.

Search for more literature for 3.1.3.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression of presqualene diphosphate phosphatase in COS-7 cells, co-expression with CTP:phosphocholine cytidylyltransferase-alpha	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	presqualene diphosphate phosphatase, i.e. PA-PSP, overexpression accelerates the synthesis of phosphatidylcholine and causes accumulation of triacylglycerol with concomitant decrease in the rate of phosphatidylinositol synthesis. Co-expression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhances the effect of PA-PSP on phosphatidylcholine levels, yet attenuates its effect on triacylglycerol, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum membrane	the enzyme active site exposed to the cytosolic side of the membrane	Homo sapiens	5789	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
32400	-	x * 32400, recombinant PA-PSP, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
a 3-sn-phosphatidate + H2O	Homo sapiens	phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols	a 1,2-diacyl-sn-glycerol + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
a 3-sn-phosphatidate + H2O	phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols	Homo sapiens	a 1,2-diacyl-sn-glycerol + phosphate	-	?
a 3-sn-phosphatidate + H2O	the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP	Homo sapiens	a 1,2-diacyl-sn-glycerol + phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 32400, recombinant PA-PSP, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PA-PSP	-	Homo sapiens
presqualene diphosphate phosphatase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)