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Literature summary for 3.1.3.4 extracted from
- Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns (2007), J. Biol. Chem., 282, 3450-3457.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of lipin-1, lipin-2, and lipin-3 in HEK-293 cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | livers of lipin-1-deficient mice exhibit normal PAP1 activity | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics of the PAP1 activities of the three lipin proteins, surface dilution kinetic model using micelles of Triton X-100, each lipin exhibits a strong positive cooperativity for phosphatidic acid | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | dependent on | Saccharomyces cerevisiae |  |
| Mg2+ | all lipins are dependent on Mg2+ | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | lipin-1 Smp2 exhibits phosphatidate phosphatase type-1 activity, which plays a key role in glycerolipid synthesis | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | lipin-1 Smp2 exhibits phosphatidate phosphatase type-1 activity, which plays a key role in glycerolipid synthesis | ? | - |
? | |
| phosphatidic acid + H2O | Mus musculus | - |
1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| phosphatidic acid + H2O | Saccharomyces cerevisiae | - |
1,2-diacyl-sn-glycerol + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
three lipins, C57BL/6J and BALB/cByJ-Lpin1+/fld mice | - |
| Saccharomyces cerevisiae | - |
a single lipin homolog, Smp2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brown adipose tissue | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| additional information | tissue expression patterns of lipin isozymes, overview, lipin-1 is responsible for PAP1 activity in adipose tissue and skeletal muscle | Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
| white adipose tissue | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | lipin-1 Smp2 exhibits phosphatidate phosphatase type-1 activity, which plays a key role in glycerolipid synthesis | Mus musculus | ? | - |
? | |
| additional information | lipin-1 Smp2 exhibits phosphatidate phosphatase type-1 activity, which plays a key role in glycerolipid synthesis | Saccharomyces cerevisiae | ? | - |
? | |
| phosphatidic acid + H2O | - |
Mus musculus | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| phosphatidic acid + H2O | - |
Saccharomyces cerevisiae | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| phosphatidic acid + H2O | lipin-1, lipin-2, and lipin-3 | Mus musculus | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | yeast PAH1 protein sequence contains a haloacid dehalogenase domain, which includes a DXDXT motif found in a superfamily of Mg2+-dependent phosphatases | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipin-1 | - |
Mus musculus |
| lipin-1 | - |
Saccharomyces cerevisiae |
| lipin-2 | - |
Mus musculus |
| lipin-3 | - |
Mus musculus |
| PAP1 | - |
Mus musculus |
| PAP1 | - |
Saccharomyces cerevisiae |
| phosphatidate phosphatase type-1 | - |
Mus musculus |
| phosphatidate phosphatase type-1 | - |
Saccharomyces cerevisiae |
| SMP2 | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Mus musculus |
| 6.5 | - |
assay at | Saccharomyces cerevisiae |
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