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Literature summary for 3.1.3.4 extracted from

  • Grkovich, A.; Johnson, C.A.; Buczynski, M.W.; Dennis, E.A.
    Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent (2006), J. Biol. Chem., 281, 32978-32987.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in P-388D1 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bromoenol lactone inhibition of PAP-1 Homo sapiens
ethanol inhibition of PAP-1 Homo sapiens
NEM inhibition of PAP-1 Homo sapiens
propranolol inhibition of PAP-1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ PAP-1, dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phosphatidic acid phosphohydrolase-1 is required for lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages or P388D1 cells, inhibition of PAP-1 results in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E2 release, regulation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell promonocytic leukemia macrophage cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphatidic acid phosphohydrolase-1 is required for lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages or P388D1 cells, inhibition of PAP-1 results in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E2 release, regulation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PAP-1
-
Homo sapiens
phosphatidic acid phosphohydrolase-1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
assay at Homo sapiens