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Literature summary for 3.1.3.4 extracted from
- FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3 (2007), FEBS Lett., 581, 3063-3068.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | LPP3 acts as an ecto-phosphatase that contributes to the equilibration between FTY720 and FTY720-P in vivo | Mus musculus |
| medicine | LPP3 acts as an ecto-phosphatase that contributes to the equilibration between FTY720 and FTY720-P in vivo | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as untagged proteins in HUVEC cells or in HEK-293 cells | Mus musculus |
| expressed either as untagged proteins or as Flag- or EGFP-tagged enzymes in HUVEC cells or in HEK-293 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | LPP1 | Homo sapiens | 5783 | - |
| plasma membrane | LPP2 and LPP3 | Homo sapiens | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | LPP3 | Homo sapiens | - |
| HUVEC cell | LPP3 | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00035 | - |
LPP3 activity against FTY720-P | Homo sapiens |
| 0.00285 | - |
LPP3 activity against sphingosine 1-phosphate | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydro-sphingosine-1-phosphate + H2O | all LPPs | Mus musculus | dihydro-sphingosine + phosphate | - |
? |  |
| dihydro-sphingosine-1-phosphate + H2O | all LPPs | Homo sapiens | dihydro-sphingosine + phosphate | - |
? | |
| FTY720-phosphate + H2O | LPP3 | Mus musculus | FTY720 + phosphate | - |
? | |
| FTY720-phosphate + H2O | LPP3 | Homo sapiens | FTY720 + phosphate | - |
? | |
| lyso-phosphatidic acid + H2O | all LPPs | Mus musculus | monoacylglycerol + phosphate | - |
? | |
| lyso-phosphatidic acid + H2O | all LPPs | Homo sapiens | monoacylglycerol + phosphate | - |
? | |
| sphingosine 1-phosphate + H2O | all LPPs | Mus musculus | sphingosine + phosphate | - |
? | |
| sphingosine 1-phosphate + H2O | all LPPs | Homo sapiens | sphingosine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipid phosphate phosphatase 3 | - |
Mus musculus |
| lipid phosphate phosphatase 3 | - |
Homo sapiens |
| lipid phosphate phosphohydrolase | - |
Mus musculus |
| lipid phosphate phosphohydrolase | - |
Homo sapiens |
| LPP1 | - |
Mus musculus |
| LPP1 | - |
Homo sapiens |
| LPP2 | - |
Homo sapiens |
| LPP3 | - |
Mus musculus |
| LPP3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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