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Literature summary for 3.1.3.4 extracted from

  • Pyne, S.; Long, J.S.; Ktistakis, N.T.; Pyne, N.J.
    Lipid phosphate phosphatases and lipid phosphate signalling (2005), Biochem. Soc. Trans., 33, 1370-1374.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of isozyme LPP1 in Rat2 fibroblasts Rattus norvegicus
separate overexpression of isozymes LPP1, LPP2, or LPP3 in HEK-293 cells reducing lysophosphatidic acid-stimulated p42/p44 MAPK activation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of LPP3 or LPP1 knockout mice, the embryonic fibroblasts of these transgenic mice show diacylglycerol levels and reduced phosphatidic acid levels Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
caveola
-
Mus musculus 5901
-
caveola
-
Homo sapiens 5901
-
caveola
-
Rattus norvegicus 5901
-
caveola
-
Canis lupus familiaris 5901
-
membrane integral Mus musculus 16020
-
membrane integral Homo sapiens 16020
-
membrane integral Rattus norvegicus 16020
-
membrane integral Canis lupus familiaris 16020
-
additional information the enzymes act intra- and extracellularly Mus musculus
-
-
additional information the enzymes act intra- and extracellularly Homo sapiens
-
-
additional information the enzymes act intra- and extracellularly Rattus norvegicus
-
-
additional information the enzymes act intra- and extracellularly, the subcellular localization influences the physiological role of the isozymes Canis lupus familiaris
-
-
plasma membrane the enzymes act on the cytoplasmic and the cell surface side of the membrane Mus musculus 5886
-
plasma membrane the enzymes act on the cytoplasmic and the cell surface side of the membrane Homo sapiens 5886
-
plasma membrane the enzymes act on the cytoplasmic and the cell surface side of the membrane Rattus norvegicus 5886
-
plasma membrane the enzymes act on the cytoplasmic and the cell surface side of the membrane, isozyme LPP1 is located at the apical membrane, isozyme LPP3 is located at the basolateral membrane Canis lupus familiaris 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidic acid + H2O Mus musculus
-
monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O Homo sapiens
-
monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O Rattus norvegicus
-
monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O Canis lupus familiaris
-
monoacylglycerol + phosphate
-
?
additional information Mus musculus LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview ?
-
?
additional information Homo sapiens LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview ?
-
?
additional information Rattus norvegicus LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview ?
-
?
additional information Canis lupus familiaris LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
isozymes LPP1, LPP-2, and LPP-3
-
Homo sapiens
-
isozymes LPP1, LPP-2, and LPP-3
-
Mus musculus
-
isozymes LPP1, LPP-2, and LPP-3
-
Rattus norvegicus
-
isozymes LPP1, LPP-2, and LPP-3
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Mus musculus
-
blood platelet
-
Homo sapiens
-
blood platelet
-
Rattus norvegicus
-
blood platelet
-
Canis lupus familiaris
-
HEK-293 cell
-
Homo sapiens
-
kidney
-
Canis lupus familiaris
-
MDCK cell Madine-Darby kidney cell line Canis lupus familiaris
-
ovary
-
Homo sapiens
-
ovary cancer cell shows reduced LPP1 activity Homo sapiens
-
preadipocyte
-
Mus musculus
-
preadipocyte
-
Homo sapiens
-
preadipocyte
-
Rattus norvegicus
-
preadipocyte
-
Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide 1-phosphate + H2O
-
Mus musculus ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Homo sapiens ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Rattus norvegicus ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Canis lupus familiaris ceramide + phosphate
-
?
lysophosphatidic acid + H2O
-
Mus musculus monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Homo sapiens monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Rattus norvegicus monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Canis lupus familiaris monoacylglycerol + phosphate
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Mus musculus ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Homo sapiens ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Rattus norvegicus ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Canis lupus familiaris ?
-
?
phosphatidic acid + H2O
-
Mus musculus diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Homo sapiens diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Rattus norvegicus diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Canis lupus familiaris diacylglycerol + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Mus musculus sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Homo sapiens sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Rattus norvegicus sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Canis lupus familiaris sphingosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
-
Mus musculus
lipid phosphate phosphatase
-
Homo sapiens
lipid phosphate phosphatase
-
Rattus norvegicus
lipid phosphate phosphatase
-
Canis lupus familiaris
LPP
-
Mus musculus
LPP
-
Homo sapiens
LPP
-
Rattus norvegicus
LPP
-
Canis lupus familiaris