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Literature summary for 3.1.3.4 extracted from

  • Long, J.; Darroch, P.; Wan, K.F.; Kong, K.C.; Ktistakis, N.; Pyne, N.J.; Pyne, S.
    Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools (2005), Biochem. J., 391, 25-32.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of LPP3 and LPP2 in HEK-293 cells, LPP2 and LPP3 are constitutively co-localized with sphingosine kinase 1, SK1, in cytoplasmic vesicles in HEK-293 cells, LPP2, not LPP3, prevents SK1 from being recruited to the perinuclear space upon induction of phospholipase D1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information caspase3/7 inhibitor N-acetyl-Asp-Glu-Val-Asp-CHO blocks cellular effects of lysophosphatidic acid and sphingosine 1-phosphate on p42/p44 MAPK pathway Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidic acid + H2O Homo sapiens
-
monoacylglycerol + phosphate
-
?
additional information Homo sapiens regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools, the enzyme reduces the stimulation of the p42/p44 MAPK signalling pathway by sphingosine 1-phosphate and lysophosphatidic acid ?
-
?
sphingosine 1-phosphate + H2O Homo sapiens
-
sphingosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes LPP1-3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidic acid + H2O
-
Homo sapiens monoacylglycerol + phosphate
-
?
additional information regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools, the enzyme reduces the stimulation of the p42/p44 MAPK signalling pathway by sphingosine 1-phosphate and lysophosphatidic acid Homo sapiens ?
-
?
sphingosine 1-phosphate + H2O
-
Homo sapiens sphingosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
-
Homo sapiens
LPP
-
Homo sapiens