Cloned (Comment) | Organism |
---|---|
cloning of two Mg2+-independent isoenzymes, PAP-2a and PAP-2b | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | post-Golgi localization | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | two Mg2+-independent isoenzymes: phosphatidic acid phosphatase PAP-1a and PAP-2b | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32158 | - |
x * 32158, isoenzyme PAP-2a, calculation from nucleotide sequence | Homo sapiens |
35119 | - |
x * 35119, isoenzyme PAP-2b, calculation from nucleotide sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | critical roles of the enzyme in cell growth and differentiation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the two Mg2+-independent isoenzymes, PAP-2a and PAP-2b are glycoproteins | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
leukocyte | peripheral blood | Homo sapiens | - |
additional information | isoenzyme PAP-2b is almost ubiquitously in all human tissues, isoenzyme PAP-2a is undetectable in thymus, placenta and leukocytes | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
prostate gland | isoenzyme PAP2a | Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide-1-phosphate + H2O | isoenzyme PAP-2a and PAP-2b | Homo sapiens | ? | - |
? | |
lysophosphatidate + H2O | isoenzyme PAP-2a and PAP-2b | Homo sapiens | ? | - |
? | |
additional information | critical roles of the enzyme in cell growth and differentiation | Homo sapiens | ? | - |
? | |
phosphatidic acid + H2O | - |
Homo sapiens | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | hydrolysis by isoenzyme PAP-2b, no hydrolysis by isoenzyme PAP-2a | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32158, isoenzyme PAP-2a, calculation from nucleotide sequence | Homo sapiens |
? | x * 35119, isoenzyme PAP-2b, calculation from nucleotide sequence | Homo sapiens |