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Literature summary for 3.1.3.36 extracted from

  • Plotnikova, O.; Seo, S.; Cottle, D.; Conduit, S.; Hakim, S.; Dyson, J.; Mitchell, C.; Smyth, I.
    INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability (2015), J. Cell Sci., 128, 364-372 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JII1 isoform INPP5E
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein centrosomal kinase AURKA phosphorylates INPP5E and thereby increases its 5-phosphatase activity Mus musculus

Synonyms

Synonyms Comment Organism
INPP5E
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Mus musculus

General Information

General Information Comment Organism
physiological function isoform INPP5E directly interacts with AURKA, a centrosomal kinase that regulates mitosis and ciliary disassembly. The interaction is important for the stability of primary cilia. AURKA phosphorylates INPP5E and thereby increases its 5-phosphatase activity, which in turn promotes transcriptional downregulation of AURKA, partly through an AKT-dependent mechanism Mus musculus