Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JII1 | isoform INPP5E | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | centrosomal kinase AURKA phosphorylates INPP5E and thereby increases its 5-phosphatase activity | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
INPP5E | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform INPP5E directly interacts with AURKA, a centrosomal kinase that regulates mitosis and ciliary disassembly. The interaction is important for the stability of primary cilia. AURKA phosphorylates INPP5E and thereby increases its 5-phosphatase activity, which in turn promotes transcriptional downregulation of AURKA, partly through an AKT-dependent mechanism | Mus musculus |