Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
SHIP2 | - |
Mus musculus |
SKIP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | in SHIP2 siRNA transfected cells, insulin treatment does not lead to alter the PIP3 level in contrast to SKIP or PTEN silenced cells. Results demonstrate that SHIP2 in contrast to SKIP is not involved in the regulation of insulin signaling in C2C12 cells | Mus musculus |
malfunction | in SKIP siRNA transfected cells, insulin treatment show an increase in PIP3 compared with control cells. Significant decrease in PI(3,4)P2 level is observed by the silencing of SKIP compared to control cells. PI(3,4)P2 levels are not altered in siRNA-transfected cells. Silencing of SKIP, increases the insulin-dependent recruitment of GLUT4 vesicles to the plasma membrane | Mus musculus |
metabolism | SKIP controls PIP3 content in an insulin stimulation-dependent manner | Mus musculus |
physiological function | SKIP negatively regulates insulin signaling and glucose uptake by inhibiting GLUT4 docking and/or fusion to the plasma membrane | Mus musculus |