Literature summary for 3.1.3.36 extracted from

Kuehbacher, A.; Dambournet, D.; Echard, A.; Cossart, P.; Pizarro-Cerda, J.
Phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection (2012), J. Biol. Chem., 287, 13128-13136.

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Organism

Organism	UniProt	Comment	Textmining
Listeria monocytogenes	-	-	-

Synonyms

Synonyms	Comment	Organism
OCRL	-	Listeria monocytogenes

General Information

General Information	Comment	Organism
malfunction	in cells knocked down for OCRL, transfection of enzymatically active EGFP-OCRL-a (but not of a phosphatase-dead enzyme) decreases the levels of intracellular Listeria monocytogenes and of actin associated with invading bacteria	Listeria monocytogenes
malfunction	inactivation of OCRL by siRNA leads to an increase in the internalization levels of Listeria monocytogenes in HeLa cells. OCRL depletion does not increase but rather decreases the surface expression of the receptor Met	Listeria monocytogenes
physiological function	by reducing the levels of PI(4,5)P2 and PI(3,4,5)P3 at the plasma membrane, OCRL restricts infection through modulation of actin dynamics at bacterial internalization sites	Listeria monocytogenes

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Release 2023.1 (January 2023)