Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
x * 100000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
IGR-3 cell | - |
Homo sapiens | - |
Mel-AT cell | - |
Homo sapiens | - |
Mel-FH cell | - |
Homo sapiens | - |
Mel-JD cell | - |
Homo sapiens | - |
Mel-RM cell | - |
Homo sapiens | - |
Mel-RMU cell | - |
Homo sapiens | - |
Mel007 cell | lowest expression | Homo sapiens | - |
melanocyte | highest expression | Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
MM200 cell | - |
Homo sapiens | - |
SK-MEL-110 cell | - |
Homo sapiens | - |
SK-MEL-28 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 100000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
inositol polyphosphate 5-phosphatase | - |
Homo sapiens |
phosphatidylinositol 4,5-bisphosphate 5-phosphatase | - |
Homo sapiens |
PI(4,5)P2 5-phosphatase A | - |
Homo sapiens |
PIB5PA | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is downregulated in human melanoma | down |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown results in increased proliferation and anchorage-independent growth of melanocytes | Homo sapiens |
physiological function | the enzyme plays a tumor suppressive role in human melanoma. Enzyme overexpression blocks Akt activation, inhibits proliferation and undermines survival of melanoma cells in vitro, and retards melanoma growth in a xenograft model | Homo sapiens |