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Literature summary for 3.1.3.36 extracted from

  • Ye, Y.; Jin, L.; Wilmott, J.S.; Hu, W.L.; Yosufi, B.; Thorne, R.F.; Liu, T.; Rizos, H.; Yan, X.G.; Dong, L.; Tay, K.H.; Tseng, H.Y.; Guo, S.T.; de Bock, C.E.; Jiang, C.C.; Wang, C.Y.; Wu, M.; Zhang, L.J.; Hersey, P.; Scolyer, R.A.; Zhang, X.D.
    PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma (2013), Nat. Commun., 4, 1508.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 x * 100000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IGR-3 cell
-
 Homo sapiens
-
Mel-AT cell
-
 Homo sapiens
-
Mel-FH cell
-
 Homo sapiens
-
Mel-JD cell
-
 Homo sapiens
-
Mel-RM cell
-
 Homo sapiens
-
Mel-RMU cell
-
 Homo sapiens
-
Mel007 cell lowest expression Homo sapiens
-
melanocyte highest expression Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
MM200 cell
-
 Homo sapiens
-
SK-MEL-110 cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 100000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
inositol polyphosphate 5-phosphatase
-
 Homo sapiens
phosphatidylinositol 4,5-bisphosphate 5-phosphatase
-
 Homo sapiens
PI(4,5)P2 5-phosphatase A
-
 Homo sapiens
PIB5PA
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in human melanoma down

General Information

General Information Comment Organism
malfunction enzyme knockdown results in increased proliferation and anchorage-independent growth of melanocytes Homo sapiens
physiological function the enzyme plays a tumor suppressive role in human melanoma. Enzyme overexpression blocks Akt activation, inhibits proliferation and undermines survival of melanoma cells in vitro, and retards melanoma growth in a xenograft model Homo sapiens