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Literature summary for 3.1.3.36 extracted from

  • Suh, B.; Leal, K.; Hille, B.
    Modulation of high-voltage activated Ca2+ channels by membrane phosphatidylinositol 4,5-bisphosphate (2010), Neuron, 67, 224-238.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.36

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Danio rerio 16020
-
plasma membrane
-
 Danio rerio 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylinositol-4,5-bisphosphate + H2O Danio rerio
-
 phosphatidylinositol-4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylinositol-4,5-bisphosphate + H2O
-
 Danio rerio phosphatidylinositol-4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol lipid 5-phosphatase
-
 Danio rerio
PIP2 5-phosphatase
-
 Danio rerio
voltage-sensitive 5-phosphatase
-
 Danio rerio
VSP
-
 Danio rerio

General Information

General Information Comment Organism
malfunction plasma membrane phosphatidylinositol-4,5-bisphosphate depletion by rapamycin-induced translocation of an inositol lipid 5-phosphatase or by a voltage-sensitive 5-phosphatase suppresses CaV1.2 and CaV1.3 channel currents by about 35% and CaV2.1 and CaV2.2 currents by 29% and 55%, respectively, mechanism, detailed overview. Other CaV channels are less sensitive. Inhibition of CaV channels by Dr-VSP is not simple voltage-dependent inhibition. Phosphatidylinositol-4,5-bisphosphate-dependent modulation of CaV2.2 channels and recovery requiring ATP and phosphatidylinositol-4,5-bisphosphate resynthesis, overview Danio rerio