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Literature summary for 3.1.3.36 extracted from

  • Lindner, M.; Leitner, M.G.; Halaszovich, C.R.; Hammond, G.R.; Oliver, D.
    Probing the regulation of TASK potassium channels by PI(4,5)P2 with switchable phosphoinositide phosphatases (2011), J. Physiol., 589, 3149-3162.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.36

Activating Compound

Activating Compound Comment Organism Structure
additional information the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, is rapidly and reversibly activated by strong depolarization of the membrane potential Homo sapiens

Protein Variants

Protein Variants Comment Organism
C392S site-directed mutagenesis, inactivating mutation in the conserved CX5R(T/S) motif of the Sac domain Homo sapiens
C641A site-directed mutagenesis, the mutation removes the prenylation site of the enzyme Homo sapiens
D556A site-directed mutagenesis, inactivating point mutation of the conserved DRVL motif of INPP5E Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane voltage-sensitive phosphoinositide phosphatase Ci-VSP Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, removes phosphatidylinositol-4,5-bisphosphate from the plasma membrane 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRR6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, removes phosphatidylinositol-4,5-bisphosphate from the plasma membrane Homo sapiens 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Ci-VSP
-
 Homo sapiens
INPP5E 5-phosphatase
-
 Homo sapiens
phosphoinositide phosphatase
-
 Homo sapiens
PI(4,5)P2-5'-phosphatase
-
 Homo sapiens
voltage-sensitive phosphoinositide phosphatase Ci-VSP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function no relevance of phosphatidylinositol-4,5-bisphosphate for the regulation of the specific ion channel type, termed TASK, and no requirement for the enzyme, overview Homo sapiens