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Literature summary for 3.1.3.36 extracted from

  • Nakatsu, F.; Perera, R.; Lucast, L.; Zoncu, R.; Domin, J.; Gertler, F.; Toomre, D.; De Camilli, P.
    The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics (2010), J. Cell Biol., 190, 307-315.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane localization of SHIP2 at clathrin-coated pits is mediated by its proline-rich region. When the targeting signal present in this domain is missing, another targeting signal that directs the protein to focal adhesion predominates, overview Mus musculus 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylinositol-3,4,5-trisphosphate + H2O Mus musculus
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phosphatidylinositol-3,4-bisphosphate + phosphate
-
?
phosphatidylinositol-4,5-bisphosphate + H2O Mus musculus
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phosphatidylinositol-4-phosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
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Mus musculus 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
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Mus musculus 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
?
phosphatidylinositol-3,4,5-trisphosphate + H2O
-
Mus musculus phosphatidylinositol-3,4-bisphosphate + phosphate
-
?
phosphatidylinositol-4,5-bisphosphate + H2O
-
Mus musculus phosphatidylinositol-4-phosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
inositol 5-phosphatase
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Mus musculus
SHIP2
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Mus musculus

General Information

General Information Comment Organism
malfunction both knockdown of SHIP2 expression and acute production of PI(3,4,5)P3 shorten clathrin-coated pits lifetime by enhancing the rate of pit maturation Mus musculus
physiological function inositol 5-phosphatase SHIP2 is a negative regulator of PI(3,4,5)P3-dependent signaling, and it also negatively regulates PI(4,5)P2 levels and is concentrated at endocytic clathrin-coated pits via interactions with the scaffold protein intersectin. SHIP2 is recruited early at the pits and dissociates before fission, positive role of both SHIP2 substrates, PI(4,5)P2 and PI(3,4,5)P3, on coat assembly, overview Mus musculus