Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | localization of SHIP2 at clathrin-coated pits is mediated by its proline-rich region. When the targeting signal present in this domain is missing, another targeting signal that directs the protein to focal adhesion predominates, overview | Mus musculus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-3,4,5-trisphosphate + H2O | Mus musculus | - |
phosphatidylinositol-3,4-bisphosphate + phosphate | - |
? | |
phosphatidylinositol-4,5-bisphosphate + H2O | Mus musculus | - |
phosphatidylinositol-4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O | - |
Mus musculus | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? | |
phosphatidylinositol-3,4,5-trisphosphate + H2O | - |
Mus musculus | phosphatidylinositol-3,4-bisphosphate + phosphate | - |
? | |
phosphatidylinositol-4,5-bisphosphate + H2O | - |
Mus musculus | phosphatidylinositol-4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol 5-phosphatase | - |
Mus musculus |
SHIP2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | both knockdown of SHIP2 expression and acute production of PI(3,4,5)P3 shorten clathrin-coated pits lifetime by enhancing the rate of pit maturation | Mus musculus |
physiological function | inositol 5-phosphatase SHIP2 is a negative regulator of PI(3,4,5)P3-dependent signaling, and it also negatively regulates PI(4,5)P2 levels and is concentrated at endocytic clathrin-coated pits via interactions with the scaffold protein intersectin. SHIP2 is recruited early at the pits and dissociates before fission, positive role of both SHIP2 substrates, PI(4,5)P2 and PI(3,4,5)P3, on coat assembly, overview | Mus musculus |