Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.36 extracted from

  • Cui, S.; Guerriero, C.; Szalinski, C.; Kinlough, C.; Hughey, R.; Weisz, O.
    OCRL1 function in renal epithelial membrane traffic (2010), Am. J. Physiol. Renal Physiol., 298, F335-F345.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.36

Protein Variants

Protein Variants Comment Organism
additional information siRNA-mediated knockdown of oculocerebrorenal syndrome of Lowe, i.e. OCRL1 in epithelial cells, phenotype, overview Homo sapiens
additional information siRNA-mediated knockdown of oculocerebrorenal syndrome of Lowe, i.e. OCRL1 in epithelial cells, phenotype, overview Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Canis lupus familiaris 16020
-

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-
epithelial cell
-
 Canis lupus familiaris
-
fibroblast
-
 Homo sapiens
-
fibroblast
-
 Canis lupus familiaris
-
HK-2 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney
-
 Canis lupus familiaris
-
MDCK cell
-
 Canis lupus familiaris
-

Synonyms

Synonyms Comment Organism
OCRL1
-
 Homo sapiens
OCRL1
-
 Canis lupus familiaris

General Information

General Information Comment Organism
malfunction no effects by siRNA-mediated OCRL1 knockdown on biosynthetic and postendocytic membrane traffic in renal epithelial cells, overview. Cells depleted of OCRL1 do not have significantly elevated levels of cellular PIP2 but display an increase in actin comet, OCRL1 knockdown results in a significant increase in secretion of the lysosomal hydrolase cathepsin D Homo sapiens
malfunction no effects by siRNA-mediated OCRL1 knockdown on biosynthetic and postendocytic membrane traffic in renal epithelial cells, overview. Cells depleted of OCRL1 do not have significantly elevated levels of cellular PIP2 but display an increase in actin comet, OCRL1 knockdown results in a significant increase in secretion of the lysosomal hydrolase cathepsin D Canis lupus familiaris
physiological function role for enzyme OCRL1 in membrane trafficking between the trans-Golgi network and endosomes, but OCRL1 does not directly modulate endocytosis or postendocytic membrane traffic Homo sapiens
physiological function role for enzyme OCRL1 in membrane trafficking between the trans-Golgi network and endosomes, but OCRL1 does not directly modulate endocytosis or postendocytic membrane traffic Canis lupus familiaris