Literature summary for 3.1.3.36 extracted from

Artemenko, Y.; Gagnon, A.; Sorisky, A.
Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes (2009), J. Cell. Physiol., 218, 228-236.

Search for more literature for 3.1.3.36

Application

Application	Comment	Organism
molecular biology	catalytically inactive SHIP2 mutant P686A/D690A/R691A reduces preadipocyte proliferation by attenuating PDGFR signaling	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in murine 3T3-L1 preadipocytes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
P686A/D690A/R691A	catalytically inactive dominant-negative mutant inhibits proliferation of preadipocytes more potently than wild-type SHIP2. Phospho-Akt, phospho-ERK1/2, and PDGF receptor (PDGFR) levels are reduced in mutant-expressing preadipocytes. The inhibition of PDGF-activated mitogenic pathways by SHIP2 mutant is consistent with a decrease in PDGFR phosphorylation caused by a drop in receptor levels in SHIP2 mutant-expressing cells. SHIP2 mutant promotes ubiquitination of the PDGFR and its degradation via the lysosomal pathway independently of the association between the E3 ubiquitin ligase c-Cbl and PDGFR	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
SHIP2	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)