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Literature summary for 3.1.3.36 extracted from
- SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF (2008), FEBS Lett., 582, 3011-3017.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | intersectin1 (ITSN1) is identified as a binding partner of the SH2 domain containing inositol 5-phosphatase 2 (SHIP2). In response to epidermal growth factor, SHIP2 expression is able to recruit the ITSN1 short form (ITSN1-S) to the cell membrane, while SHIP2 overexpression does not modulate the ITSN-mediated extracellular signal-regulated kinase1/2 and c-Jun NH2-terminal kinase activation | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells and in Saccharomyces cerevisiae | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | intersectin1 (ITSN1) is identified as a new binding partner of the SH2 domain containing inositol 5-phosphatase 2 (SHIP2) | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | intersectin1 (ITSN1) is identified as a new binding partner of the SH2 domain containing inositol 5-phosphatase 2 (SHIP2) | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SH2 domain containing inositol 5-phosphatase 2 | - |
Homo sapiens |
| SHIP2 | - |
Homo sapiens |
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