Literature summary for 3.1.3.36 extracted from

Buettner, R.; Ottinger, I.; Gerhardt-Salbert, C.; Wrede, C.E.; Schoelmerich, J.; Bollheimer, L.C.
Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome (2007), Am. J. Physiol. Endocrinol. Metab., 292, E1871-E1878.

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Application

Application	Comment	Organism
medicine	a SHIP2-antisense oligonucleotide therapy can improve the decrease in insulin-induced glucose disposal observed after high-fat feeding. This effect can be retraced on a molecular level by an improvement in insulin-induced Akt phosphorylation	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	whole body insulin sensitivity is examined in vivo by insulin tolerance tests before and after the intraperitoneal application of an SHIP2-antisense oligonucleotide. Treatment with a SHIP2-antisense oligonucleotide can rapidly improve muscle insulin sensitivity in dietary insulin resistance	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
lipid phosphatase SHIP2	-	Rattus norvegicus

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Release 2023.1 (January 2023)