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Literature summary for 3.1.3.36 extracted from
- Phosphomonoesterase hydrolysis of polyphosphoinositides in rat kidney: Properties and subcellular localization of the enzyme system (1975), Biochem. J., 150, 537-551.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cetyltrimethylammonium bromide | only activates when added with the substrate and in the presence of Mg2+ | Rattus norvegicus |  |
| Cutsum | - |
Rattus norvegicus | |
| sodium deoxycholate | - |
Rattus norvegicus | |
| Triton X-100 | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Rattus norvegicus | |
| Li+ | activates | Rattus norvegicus | |
| Mg2+ | activated | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | the enzyme is more active in the kidney cortex than in the medulla | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidyl-myo-inositol 4,5-bisphosphate + H2O | - |
Rattus norvegicus | phosphatidylinositol 4-phosphate + phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.3 | pH 6.5: about 60% of maximal activity, pH 8.3: about 50% of maximal activity | Rattus norvegicus |
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