BRENDA - Reference to 3.1.3.36; Id = 134805

0.25

-

phosphatidyl-myo-inositol 4,5-bisphosphate

-

Homo sapiens

cytoskeleton

-

Homo sapiens

5856

-

cytosol

-

Homo sapiens

5829

-

membrane

-

Homo sapiens

16020

-

Ca2+

no requirement

Homo sapiens

Mg2+

required

Homo sapiens

-

platelet

-

Homo sapiens

-

phosphatidyl-myo-inositol 4,5-bisphosphate + H2O

-

134805

Homo sapiens

phosphatidylinositol 4-phosphate + phosphate

-

134805

Homo sapiens

?

0.25

-

phosphatidyl-myo-inositol 4,5-bisphosphate

-

Homo sapiens

cytoskeleton

-

Homo sapiens

5856

-

cytosol

-

Homo sapiens

5829

-

membrane

-

Homo sapiens

16020

-

Ca2+

no requirement

Homo sapiens

Mg2+

required

Homo sapiens

platelet

-

Homo sapiens

-

phosphatidyl-myo-inositol 4,5-bisphosphate + H2O

-

134805

Homo sapiens

phosphatidylinositol 4-phosphate + phosphate

-

134805

Homo sapiens

?

751562

Cestari

Nuclear phosphatidylinositol ...

Trypanosoma brucei

Mol. Cell. Biol.

39

e00395-18

2019

-

1

-

3

1

-

1

-

2

-

1

-

3

-

1

-

3

1

-

2

-

3

-

1

-

3

751176

Chen

SAC-1 ensures epithelial endo ...

Caenorhabditis elegans

J. Cell Biol.

217

2121-2139

2018

-

1

-

1

-

1

-

1

2

-

1

-

1

-

1

-

2

-

749902

Mills

Crystal Structures of type-II ...

Homo sapiens

Biochemistry

55

1384-1397

2016

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

751086

Kume

The pleckstrin homology domai ...

Homo sapiens

J. Biol. Chem.

291

8150-8161

2016

-

1

-

1

-

1

2

-

1

-

1

-

752049

Keum

Phosphoinositide 5- and 3-pho ...

Danio rerio

Proc. Natl. Acad. Sci. USA

113

E3686-E3695

2016

-

1

-

3

-

2

-

3

-

751178

Plotnikova

INPP5E interacts with AURKA, ...

Mus musculus

J. Cell Sci.

128

364-372

2015

-

1

-

1

-

1

-

1

-

1

-

730981

Braun

Membrane interaction and funct ...

Homo sapiens

Structure

22

664-666

2014

-

2

-

2

-

2

-

2

-

6

-

2

-

2

-

2

-

1

-

730984

Tresaugues

Structural basis for phosphoin ...

Homo sapiens

Structure

22

744-755

2014

-

2

-

2

-

2

-

5

-

2

-

4

-

2

-

2

-

2

-

2

-

729949

Miyazawa

Phosphoinositide 5-phosphatase ...

Homo sapiens

J. Biochem.

153

1-3

2013

-

2

-

1

-

2

-

2

-

2

-

2

-

1

-

1

-

730456

Ye

PI(4,5)P2 5-phosphatase A regu ...

Homo sapiens

Nat. Commun.

4

1508

2013

-

1

-

4

-

12

-

1

4

-

1

-

12

-

1

-

1

2

1

-

729995

Ijuin

Role of phosphatidylinositol 3 ...

Homo sapiens, Mus musculus

J. Biol. Chem.

287

31330-31341

2012

-

1

-

2

-

4

-

1

-

5

-

1

-

4

-

1

-

2

6

2

-

732045

Kuehbacher

Phosphatidylinositol 5-phospha ...

Listeria monocytogenes

J. Biol. Chem.

287

13128-13136

2012

-

1

-

1

-

3

-

732083

Ijuin

Regulation of insulin signalin ...

Mus musculus

J. Biol. Chem.

287

6991-6999

2012

-

1

-

1

-

2

-

1

-

4

-

732476

Mondal

Phosphoinositide lipid phospha ...

Mus musculus

Mol. Biol. Cell

23

1219-1230

2012

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

732478

Kato

The inositol 5-phosphatase SHI ...

Homo sapiens

Mol. Biol. Cell

23

2593-2604

2012

-

3

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

2

-

714679

Deng

Influence of proline-rich inos ...

Mus musculus, Mus musculus Kunming

Cell Prolif.

44

156-165

2011

-

1

-

1

-

4

-

4

-

3

-

4

-

2

-

1

-

1

-

4

-

3

-

4

-

2

-

714782

Ben El Kadhi

The inositol 5-phosphatase dOC ...

Drosophila melanogaster

Curr. Biol.

21

1074-1079

2011

-

2

-

1

-

5

-

1

-

2

-

2

-

1

-

1

-

2

-

716022

Lindner

Probing the regulation of TASK ...

Homo sapiens

J. Physiol.

589

3149-3162

2011

1

-

3

-

1

-

1

-

1

-

2

-

5

-

1

-

3

-

1

-

1

-

2

-

1

-

716304

Dambournet

Rab35 GTPase and OCRL phosphat ...

Homo sapiens

Nat. Cell Biol.

13

981-988

2011

-

1

-

1

-

3

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

3

-

716624

Kaye

Inositol polyphosphate 5-phosp ...

Arabidopsis thaliana

Plant Physiol.

157

229-241

2011

-

1

-

2

-

4

-

1

-

2

-

716657

Vollmer

Unique cell wall abnormalities ...

Arabidopsis thaliana, Arabidopsis thaliana CS1092

Planta

234

993-1005

2011

-

1

-

4

-

2

-

2

-

1

-

2

-

1

-

713723

Cui

OCRL1 function in renal epithe ...

Canis lupus familiaris, Homo sapiens

Am. J. Physiol. Renal Physiol.

298

F335-F345

2010

-

2

-

2

-

8

-

8

-

2

-

2

-

2

-

8

-

4

-

714675

Bakowski

The phosphoinositide phosphata ...

Salmonella enterica

Cell Host Microbe

7

453-462

2010

-

1

-

3

-

1

-

2

-

1

-

1

-

3

-

715707

Nakatsu

The inositol 5-phosphatase SHI ...

Mus musculus

J. Cell Biol.

190

307-315

2010

-

1

-

2

-

1

-

4

-

2

-

1

-

2

-

4

-

2

-

716164

Fabian

Phosphatidylinositol 4,5-bisph ...

Drosophila melanogaster

Mol. Biol. Cell

21

1546-1555

2010

-

1

-

1

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

2

-

1

-

716225

Soeda

The inositol phosphatase SHIP2 ...

Mus musculus, Mus musculus C57/BL6J

Mol. Endocrinol.

24

1965-1977

2010

-

1

-

7

-

3

-

3

-

1

-

3

-

1

2

1

-

716345

Suh

Modulation of high-voltage act ...

Danio rerio

Neuron

67

224-238

2010

-

2

-

1

-

1

-

1

-

4

-

2

-

1

-

1

-

1

-

716921

Broberg

A Vibrio effector protein is a ...

Vibrio parahaemolyticus

Science

329

1660-1662

2010

-

4

-

2

-

8

-

2

1

3

-

4

-

2

-

2

1

-

2

-

691698

Hung

Suppression of hepatitis B vir ...

Homo sapiens

Cell. Microbiol.

11

37-50

2009

-

1

-

4

-

2

-

4

-

3

-

1

-

4

-

2

-

693264

Choudhury

Differential clathrin binding ...

Homo sapiens

J. Biol. Chem.

284

9965-9973

2009

-

1

-

3

-

3

-

1

-

1

-

1

-

1

-

1

-

3

-

3

-

1

-

1

-

693329

Artemenko

Catalytically inactive SHIP2 i ...

Homo sapiens

J. Cell. Physiol.

218

228-236

2009

-

1

-

1

-

1

-

1

-

1

-

1

-

702258

Zhang

The SH2 domains of inositol po ...

Homo sapiens

Biochemistry

48

11075-11083

2009

-

2

-

2

-

1

-

1

-

1

-

3

-

2

-

2

-

1

-

1

-

681038

Onnockx

The association between the SH ...

Homo sapiens

J. Cell. Physiol.

214

260-272

2008

-

1

-

1

-

2

1

-

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

1

-

1

-

1

-

682328

Chen

An inositol polyphosphate 5-ph ...

Arabidopsis thaliana

Plant Cell

20

353-366

2008

-

1

-

1

-

1

-

7

-

1

-

2

-

2

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

691699

Weber

The inositol polyphosphate 5-p ...

Dictyostelium discoideum, Homo sapiens, Mus musculus

Cell. Microbiol.

11

442-460

2008

-

1

-

5

-

5

-

12

-

1

-

9

-

1

-

5

-

5

-

1

-

691713

Xie

The docking properties of SHIP ...

Homo sapiens

Cell. Signal.

20

1432-1441

2008

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

691787

Mills

Benzene polyphosphates as tool ...

Homo sapiens

ChemBioChem

9

1757-1766

2008

-

9

-

1

-

1

-

1

-

1

-

9

-

9

-

1

-

1

-

692357

Xie

SHIP2 associates with intersec ...

Homo sapiens

FEBS Lett.

582

3011-3017

2008

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

693056

Thyagarajan

Hydrolysis of phosphatidylinos ...

Homo sapiens

J. Biol. Chem.

283

14980-14987

2008

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

677466

Buettner

Antisense oligonucleotides aga ...

Rattus norvegicus

Am. J. Physiol. Endocrinol. Metab.

292

E1871-E1878

2007

-

1

-

1

-

7

-

1

-

1

-

1

-

1

-

1

-

678074

Batty

The control of phosphatidylino ...

Homo sapiens, Mus musculus

Biochem. J.

407

255-266

2007

2

-

1

-

2

-

3

2

-

2

-

1

-

4

-

4

-

6

1

-

2

-

2

-

1

-

2

-

3

2

-

1

-

4

-

4

-

1

-

2

-

679150

Zhang

SHIP2 controls PtdIns(3,4,5)P( ...

Mus musculus

Cell. Signal.

19

2194-2200

2007

-

1

-

1

-

3

-

2

-

1

-

1

-

679439

Grempler

Normalization of prandial bloo ...

Mus musculus

Diabetes

56

2235-2241

2007

-

1

-

1

-

4

-

1

-

2

-

1

-

1

-

1

-

681002

van Zeijl

Regulation of connexin43 gap j ...

Homo sapiens

J. Cell Biol.

177

881-891

2007

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

681014

Williams

Targeting of the type II inosi ...

Homo sapiens

J. Cell Sci.

120

3941-3951

2007

-

1

-

3

-

1

-

4

-

2

-

1

-

3

-

1

-

681213

Leung

The inositol 5-phosphatase SHI ...

Mus musculus

J. Immunol.

179

95-102

2007

-

1

-

2

-

3

-

1

-

682069

Nishio

Control of cell polarity and m ...

Mus musculus

Nat. Cell Biol.

9

36-44

2007

-

1

-

2

-

2

-

1

-

682125

Mani

The dual phosphatase activity ...

Homo sapiens

Neuron

56

1004-1018

2007

-

3

-

1

-

5

-

2

-

2

1

-

1

-

3

-

1

-

2

-

1

-

1

-

682938

Loovers

Regulation of phagocytosis in ...

Dictyostelium discoideum

Traffic

8

618-628

2007

-

3

-

13

-

1

-

3

-

677869

Vinciguerra

PTEN and SHIP2 phosphoinositid ...

Chlorocebus aethiops, Cricetulus griseus, Mus musculus

Arch. Physiol. Biochem.

112

89-104

2006

-

1

3

-

5

-

3

-

6

-

3

-

3

-

1

3

-

5

-

6

-

3

-

678188

Andersen

A secreted salivary inositol p ...

Rhodnius prolixus

Biochemistry

45

5450-5457

2006

2

-

1

-

1

2

-

1

-

3

-

1

-

1

-

3

-

2

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

3

-

1

-

1

-

679145

Vaillancourt

The Src homology 2-containing ...

Homo sapiens

Cell. Signal.

18

2022-2032

2006

-

1

-

1

-

4

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

679146

Vandeput

The influence of anionic lipid ...

Homo sapiens

Cell. Signal.

18

2193-2199

2006

3

-

1

-

1

-

1

-

1

-

2

-

3

-

4

1

-

1

-

3

-

1

-

1

-

1

-

2

-

3

-

1

-

1

-

679517

Bertelli

Phosphoinositide-specific inos ...

Rattus norvegicus

Endocrinology

147

5385-5399

2006

-

1

-

4

-

1

-

1

-

2

-

1

-

1

-

1

-

680062

Kimata

Actin organization and hepatoc ...

Rattus norvegicus

Hepatology

44

140-151

2006

-

1

-

2

-

1

-

2

-

1

-

1

-

682526

Perera

Two synaptojanin 1 isoforms ar ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

103

19332-19337

2006

-

1

2

-

2

-

2

-

1

-

2

-

3

-

1

2

-

2

-

2

-

2

-

663940

Johenning

InsP3-mediated intracellular c ...

Homo sapiens

Biochem. J.

382

687-694

2004

-

1

-

2

-

1

-

1

-

3

-

4

1

-

1

-

1

-

2

-

1

-

3

-

1

-

1

-

664945

Schmid

Type II phosphoinositide 5-pho ...

Homo sapiens, Mus musculus, Rattus norvegicus

FEBS Lett.

576

9-13

2004

-

3

-

3

-

3

-

17

-

10

3

-

3

-

3

-

3

-

17

-

3

-

3

-

665564

Morales-Johansson

Negative regulation of phospha ...

Saccharomyces cerevisiae, Saccharomyces cerevisiae TB50

J. Biol. Chem.

279

39604-39610

2004

2

-

1

-

2

-

4

-

1

-

4

-

2

1

-

1

-

2

-

1

-

2

-

1

-

4

-

1

-

1

-

665575

Chi

Comparative mechanistic and su ...

Schizosaccharomyces pombe

J. Biol. Chem.

279

44987-44995

2004

-

1

-

1

-

2

-

4

-

1

-

6

-

1

-

15

1

3

1

-

1

-

1

-

1

-

1

-

2

1

2

-

4

-

1

-

1

-

15

1

-

1

-

666576

Zhong

FRAGILE FIBER3, an Arabidopsis ...

Arabidopsis thaliana

Plant Cell

16

3242-3259

2004

-

1

-

1

-

1

-

2

-

8

-

5

-

6

1

5

1

-

1

-

1

-

1

-

1

-

2

-

5

-

6

1

-

1

-

666585

Zhong

Molecular and biochemical char ...

Arabidopsis thaliana

Plant Cell Physiol.

45

1720-1728

2004

-

1

-

1

-

1

-

1

-

8

-

1

-

6

-

5

1

4

-

1

-

1

-

1

-

1

-

1

-

6

-

5

1

-

652022

Kong

Cloning and characterization o ...

Mus musculus

J. Biol. Chem.

275

24052-24064

2000

-

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

1

-

2

1

-

653244

Roschinger

Carrier assessment in families ...

Homo sapiens

Mol. Genet. Metab.

69

213-222

2000

-

1

-

1

-

3

-

1

-

1

-

134820

Zhang

Cell lines from kidney proxima ...

Homo sapiens

J. Biol. Chem.

273

1574-1582

1998

-

2

1

-

2

-

1

-

1

-

6

-

2

1

-

2

-

1

-

6

-

134818

Sakisaka

Phosphatidylinositol 4,5-bisph ...

Bos taurus

Mol. Cell. Biol.

17

3841-3849

1997

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

1

-

2

-

134819

Zhang

The protein deficient in Lowe ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

92

4853-4856

1995

-

1

-

1

-

4

-

1

-

4

-

1

-

1

-

1

-

4

-

134821

Suchy

Lowe syndrome, a deficiency of ...

Homo sapiens

Hum. Mol. Genet.

4

2245-2250

1995

-

1

-

2

-

4

-

1

-

3

-

1

-

2

-

1

-

3

-

134805

Matzaris

Identification and characteriz ...

Homo sapiens

J. Biol. Chem.

269

3397-33402

1994

-

1

3

2

-

3

-

1

-

1

-

1

3

2

-

1

-

1

-

134823

Palmer

Purification of two immunologi ...

Bos taurus

J. Biol. Chem.

269

3403-3410

1994

-

1

-

3

1

-

3

-

1

-

1

3

1

-

1

-

3

1

-

1

-

1

3

1

-

134822

Palmer

Enzymes that degrade phosphati ...

Gallus gallus

Biochem. Cell Biol.

68

800-803

1990

-

1

-

1

-

1

-

1

-

1

-

134808

Mack

Soluble and membrane-bound pol ...

Oryctolagus cuniculus, Ovis aries, Homo sapiens, Rattus norvegicus, Sus scrofa

Biochem. Cell Biol.

66

199-207

1988

-

9

8

-

12

-

3

-

5

-

9

8

-

3

-

5

-

134807

Mack

Evidence for a specific phosph ...

Canis lupus familiaris, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Platyrrhini, Rattus norvegicus

J. Lipid Res.

25

75-85

1984

-

12

4

-

16

-

5

-

6

-

12

4

-

5

-

6

-

134809

Koutouzov

The Mg2+-activated phosphatidy ...

Rattus norvegicus

FEBS Lett.

144

16-20

1982

-

1

2

-

1

-

1

-

1

-

1

2

-

1

-

1

-

134810

Roach

Human erythrocyte cytosol phos ...

Homo sapiens

Biochim. Biophys. Acta

661

323-333

1981

-

2

4

1

2

1

-

4

-

1

-

2

1

3

1

-

1

-

1

-

2

-

4

-

1

2

1

-

1

-

2

1

3

1

-

1

-

1

-

134811

Palmer

The phosphatidyl-myo-inositol- ...

Crithidia fasciculata

Can. J. Biochem.

59

469-476

1981

-

7

1

-

2

-

1

-

1

-

2

-

2

1

-

7

-

1

-

2

-

1

-

2

-

2

1

-

134813

Whiting

Enzymes of myo-inositol and in ...

Rattus norvegicus

Biochem. J.

179

549-553

1979

-

1

-

5

-

2

-

2

-

1

-

2

-

2

-

134812

Akhtar

Studies on the properties of t ...

Oryctolagus cuniculus

Biochim. Biophys. Acta

527

159-170

1978

3

-

3

-

1

3

-

6

-

3

-

1

-

1

-

1

-

3

-

3

-

1

3

-

3

-

1

-

1

-

1

-

134817

Abdel-Latif

Acetylcholine increases breakd ...

Oryctolagus cuniculus

Biochem. J.

162

61-73

1977

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

134816

Lefebvre

Diphosphoinositide metabolism ...

Bos taurus

Can. J. Biochem.

54

746-753

1976

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

134815

Cooper

Phosphomonoesterase hydrolysis ...

Rattus norvegicus

Biochem. J.

150

537-551

1975

-

4

-

1

3

-

2

-

1

-

1

-

1

-

4

-

1

3

-

1

-

1

-

1

-

134814

Sheltawy

The subcellular distribution o ...

Cavia porcellus

Biochem. J.

128

579-586

1972

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

134806

Dawson

The triphosphoinositide phosph ...

Bos taurus

Biochem. J.

91

244-250

1964

1

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

Identification and characterization of the phosphatidylinositol-(4,5)-bisphosphate 5-phosphatase in human platelets

Data extracted from this reference: