BRENDA - Enzyme Database
show all sequences of 3.1.3.31

Partial purification and properties of an AMP-specific 5'-nucleotidase from pigeon heart

Skladanowski, A.C.; Newby, A.C.; Biochem. J. 268, 117-122 (1990)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
ADP
-
Columba livia
additional information
not activated by ATP
Columba livia
Inhibitors
Inhibitors
Commentary
Organism
Structure
4-nitrophenyl phosphate
49.9% inhibition at 10 mM
Columba livia
5'-deoxy-5'-isobutylthioadenosine
21.1% inhibition at 3 mM
Columba livia
5'-deoxy-5'-isobutylthioinosine
54.8% inhibition at 7 mM
Columba livia
CMP
55.4% inhibition at 10 mM
Columba livia
D-ribose 5-phosphate
14.2% inhibition at 10 mM
Columba livia
dAMP
66.1% inhibition at 10 mM
Columba livia
GMP
42.7% inhibition at 10 mM
Columba livia
IMP
36% inhibition at 10 mM
Columba livia
Mg2+
inhibitory at 10 mM and above
Columba livia
additional information
not inhibited by [alpha,beta-methylene]ADP
Columba livia
phosphate
31.7% inhibition at 20 mM
Columba livia
UMP
74.5% inhibition at 10 mM
Columba livia
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Columba livia
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required for activity
Columba livia
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
150000
-
gel filtration
Columba livia
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
AMP + H2O
Columba livia
100% activity, 15fold preference for AMP over IMP
adenosine + phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Columba livia
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate precipitation, phosphocellulose column chromatography, and UltraPak TSK G4000gel filtration
Columba livia
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Columba livia
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.17
-
crude enzyme from supernatant, at pH 6.5 and 37°C
Columba livia
35.83
-
after 211fold purification, at pH 6.5 and 37°C
Columba livia
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
AMP + H2O
100% activity, 15fold preference for AMP over IMP
95065
Columba livia
adenosine + phosphate
-
-
-
?
CMP + H2O
61.7% activity compared to AMP
95065
Columba livia
cytosine + phosphate
-
-
-
?
dAMP + H2O
66% activity compared to AMP
95065
Columba livia
deoxyadenosine + phosphate
-
-
-
?
dCMP + H2O
12.1% activity compared to AMP
95065
Columba livia
deoxycytosine + phosphate
-
-
-
?
dGMP + H2O
49.9% activity compared to AMP
95065
Columba livia
deoxyguanosine + phosphate
-
-
-
?
dIMP + H2O
60.9% activity compared to AMP
95065
Columba livia
deoxyinosine + phosphate
-
-
-
?
GMP + H2O
33.5% activity compared to AMP
95065
Columba livia
guanosine + phosphate
-
-
-
?
IMP + H2O
33.1% activity compared to AMP
95065
Columba livia
inosine + phosphate
-
-
-
?
additional information
very low rates of dephosphorylation with beta-glycerophosphate, D-ribose 5-phosphate and 4-nitrophenyl phosphate, while 3',5'-cyclic AMP is not hydrolysed significantly
95065
Columba livia
?
-
-
-
-
TMP + H2O
15.2% activity compared to AMP
95065
Columba livia
thymidine + phosphate
-
-
-
?
UMP + H2O
49.5% activity compared to AMP
95065
Columba livia
uridine + phosphate
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Columba livia
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
ADP
-
Columba livia
additional information
not activated by ATP
Columba livia
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-nitrophenyl phosphate
49.9% inhibition at 10 mM
Columba livia
5'-deoxy-5'-isobutylthioadenosine
21.1% inhibition at 3 mM
Columba livia
5'-deoxy-5'-isobutylthioinosine
54.8% inhibition at 7 mM
Columba livia
CMP
55.4% inhibition at 10 mM
Columba livia
D-ribose 5-phosphate
14.2% inhibition at 10 mM
Columba livia
dAMP
66.1% inhibition at 10 mM
Columba livia
GMP
42.7% inhibition at 10 mM
Columba livia
IMP
36% inhibition at 10 mM
Columba livia
Mg2+
inhibitory at 10 mM and above
Columba livia
additional information
not inhibited by [alpha,beta-methylene]ADP
Columba livia
phosphate
31.7% inhibition at 20 mM
Columba livia
UMP
74.5% inhibition at 10 mM
Columba livia
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Columba livia
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required for activity
Columba livia
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
150000
-
gel filtration
Columba livia
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
AMP + H2O
Columba livia
100% activity, 15fold preference for AMP over IMP
adenosine + phosphate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate precipitation, phosphocellulose column chromatography, and UltraPak TSK G4000gel filtration
Columba livia
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Columba livia
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.17
-
crude enzyme from supernatant, at pH 6.5 and 37°C
Columba livia
35.83
-
after 211fold purification, at pH 6.5 and 37°C
Columba livia
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
AMP + H2O
100% activity, 15fold preference for AMP over IMP
95065
Columba livia
adenosine + phosphate
-
-
-
?
CMP + H2O
61.7% activity compared to AMP
95065
Columba livia
cytosine + phosphate
-
-
-
?
dAMP + H2O
66% activity compared to AMP
95065
Columba livia
deoxyadenosine + phosphate
-
-
-
?
dCMP + H2O
12.1% activity compared to AMP
95065
Columba livia
deoxycytosine + phosphate
-
-
-
?
dGMP + H2O
49.9% activity compared to AMP
95065
Columba livia
deoxyguanosine + phosphate
-
-
-
?
dIMP + H2O
60.9% activity compared to AMP
95065
Columba livia
deoxyinosine + phosphate
-
-
-
?
GMP + H2O
33.5% activity compared to AMP
95065
Columba livia
guanosine + phosphate
-
-
-
?
IMP + H2O
33.1% activity compared to AMP
95065
Columba livia
inosine + phosphate
-
-
-
?
additional information
very low rates of dephosphorylation with beta-glycerophosphate, D-ribose 5-phosphate and 4-nitrophenyl phosphate, while 3',5'-cyclic AMP is not hydrolysed significantly
95065
Columba livia
?
-
-
-
-
TMP + H2O
15.2% activity compared to AMP
95065
Columba livia
thymidine + phosphate
-
-
-
?
UMP + H2O
49.5% activity compared to AMP
95065
Columba livia
uridine + phosphate
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Columba livia
Other publictions for EC 3.1.3.31
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750046
Kozarski
7-Methylguanosine monophospha ...
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Bioorg. Med. Chem.
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191-199
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1
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1
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2
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750791
Trundova
Highly stable single-strand-s ...
Legionella pneumophila subsp. pneumophila, Legionella pneumophila subsp. pneumophila Philadelphia 1
Int. J. Biol. Macromol.
114
776-787
2018
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1
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1
1
1
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1
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6
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1
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4
1
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1
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1
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1
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1
1
1
1
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1
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1
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4
1
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1
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749534
Salman
Characterization of ectonucle ...
Rattus norvegicus
Am. J. Physiol. Cell Physiol.
313
C274-C284
2017
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2
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2
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750037
Fiene
Inhibitors for the bacterial ...
Legionella pneumophila 130b, Legionella pneumophila
Bioorg. Med. Chem.
24
4363-4371
2016
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1
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25
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4
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7
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1
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6
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5
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2
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1
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2
25
5
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4
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1
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6
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751345
Luchter-Wasylewska
-
Homotropic allostery of nucle ...
Homo sapiens
J. Mol. Catal. B
128
73-77
2016
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4
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1
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1
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4
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4
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4
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1
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4
-
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-
4
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4
4
751279
Laketa
Brain injury alters ectonucle ...
Rattus norvegicus
J. Med. Biochem.
34
215-222
2015
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3
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3
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3
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3
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3
-
-
-
-
-
-
-
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1
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-
1
-
-
751403
Cabello-Diaz
Identification and characteri ...
Phaseolus vulgaris
J. Plant Physiol.
185
44-51
2015
-
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1
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2
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1
1
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4
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1
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1
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7
1
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2
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1
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1
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1
2
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1
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1
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1
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7
1
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2
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1
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1
-
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729545
Bageritz
Stem cell characteristics in g ...
Homo sapiens
Cell Death Differ.
21
929-940
2014
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1
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1
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1
1
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729691
Prunetti
Structural and biochemical pro ...
Haloferax volcanii, Haloferax volcanii DS2
Extremophiles
18
283-293
2013
1
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1
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1
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1
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9
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1
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1
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6
1
1
1
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1
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1
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6
1
1
1
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716430
Zarlenga
A calcium-activated nucleotida ...
Ostertagia ostertagi, Ostertagia ostertagi L4
Parasitology
138
333-343
2011
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1
1
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7
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8
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2
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8
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1
1
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691895
Jensen
ATP release and extracellular ...
Oncorhynchus mykiss
Comp. Biochem. Physiol. A
152
351-356
2009
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1
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3
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3
1
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694690
Wilson
The nucleotidase/phosphatase S ...
Arabidopsis thaliana
Plant J.
58
299-317
2009
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1
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678347
Yang
Characterization and importanc ...
Homo sapiens
Biochemistry
47
771-778
2008
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1
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4
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5
1
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2
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1
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7
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1
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4
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1
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1
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7
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682900
Yang
Engineered human soluble calci ...
Cimex lectularius, Homo sapiens
Thromb. Res.
122
541-548
2008
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2
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2
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2
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7
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3
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8
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2
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3
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8
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691000
Ivanenkov
Trafficking and intracellular ...
Homo sapiens
Biochemistry
47
9184-9197
2008
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1
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4
-
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2
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1
1
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1
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1
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1
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4
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1
1
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1
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1
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691559
Ghisleni
Selenium compounds counteract ...
Rattus norvegicus
Brain Res.
1221
134-140
2008
1
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1
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1
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691919
Sales
-
Nucleotidase and DNase activit ...
Bothrops alcatraz, Bothrops alternatus, Bothrops atrox, Bothrops brazili, Bothrops cotiara, Bothrops diporus, Bothrops erythromelas, Bothrops fonsecai, Bothrops insularis, Bothrops itapetiningae, Bothrops jararaca, Bothrops jararacussu, Bothrops marajoensis, Bothrops matogrossensis, Bothrops moojeni, Bothrops neuwiedi, Bothrops pauloensis, Bothrops pirajai, Bothrops pradoi, Bothrops pubescens, Bothrops taeniatus, Crotalus adamanteus, Crotalus durissus, Crotalus durissus cumanensis, Lachesis muta, Micrurus frontalis, no activity in Loxosceles gaucho, no activity in Philodryas olfersii
Comp. Biochem. Physiol. C
147C
85-95
2008
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26
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26
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692192
Pedrazza
Ecto-nucleotidase pathway is a ...
Rattus norvegicus, Rattus norvegicus Wistar
Eur. J. Pharmacol.
583
18-25
2008
2
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694864
Frederick
A role for a lithium-inhibited ...
Mus musculus
Proc. Natl. Acad. Sci. USA
105
11605-11612
2008
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729916
Zhou
Proteasomal components require ...
Haloferax volcanii, Haloferax volcanii DS2
J. Bacteriol.
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8096-8105
2008
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1
1
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665044
Devader
Xenopus apyrase (xapy), a secr ...
Xenopus laevis
Gene
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135-141
2006
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1
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6
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4
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680687
Yang
Calcium-dependent dimerization ...
Homo sapiens
J. Biol. Chem.
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28307-28317
2006
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1
1
8
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8
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1
1
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1
1
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681602
Yegutkin
Intravascular ADP and soluble ...
Homo sapiens
J. Physiol.
579
553-564
2006
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656266
Proudfoot
General Enzymatic Screens Iden ...
Escherichia coli
J. Biol. Chem.
279
54687-54694
2004
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12
18
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6
5
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1
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18
3
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12
4
18
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6
5
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1
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15
2
1
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18
3
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664646
Borges
-
Nucleotidase activities in mem ...
Helix aspersa
Comp. Biochem. Physiol. B
137B
297-307
2004
3
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3
4
1
2
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1
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8
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3
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3
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1
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1
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8
-
1
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2
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654871
Passariello
The molecular class C acid pho ...
Elizabethkingia meningoseptica
Biochim. Biophys. Acta
1648
203-209
2003
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1
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1
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10
10
1
2
2
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4
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1
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1
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10
1
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10
1
1
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9
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1
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1
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9
10
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10
1
2
2
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1
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1
-
10
1
-
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10
1
1
-
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656785
Vance
Repair of DNA strand breaks by ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
21
7191-7198
2001
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1
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1
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1
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1
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2
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-
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-
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654913
Tikhaya
-
Biochemical adaptation of barl ...
Hordeum vulgare
Biol. Bull.
27
579-584
2000
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3
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3
2
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1
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2
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1
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1
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-
655137
Nikbakht
Complex hippocampal responses ...
Rattus norvegicus
Brain Res.
860
161-165
2000
-
-
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2
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2
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1
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1
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-
-
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-
81060
Hoglund
Cytoplasmic 5'(3')-nucleotidas ...
Homo sapiens
J. Biol. Chem.
265
6589-6598
1990
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-
-
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3
12
2
3
2
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4
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3
1
1
12
1
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1
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3
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12
2
3
2
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3
1
1
12
1
-
-
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-
1
-
-
-
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-
-
-
-
-
95065
Skladanowski
Partial purification and prope ...
Columba livia
Biochem. J.
268
117-122
1990
2
-
-
-
-
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12
-
1
1
1
1
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1
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1
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1
2
-
11
-
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1
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2
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12
-
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1
1
1
1
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1
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1
2
-
11
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
81057
Yokoyama
-
Purification and characterizat ...
Glycine max
Agric. Biol. Chem.
53
83-88
1989
-
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-
-
-
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1
1
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1
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1
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1
1
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10
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1
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1
2
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1
1
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1
-
1
1
-
10
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
81058
Hokari
Rat spleen cytoplasmic nucleot ...
Rattus norvegicus
Int. J. Biochem.
20
1405-1410
1988
-
-
-
-
-
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-
8
2
-
1
1
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3
-
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1
-
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7
-
-
19
-
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2
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-
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8
2
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1
1
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1
-
7
-
-
19
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
81059
Haugen
Cellular localization and deve ...
Rattus norvegicus
Int. J. Biochem.
19
193-196
1987
-
-
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-
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2
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8
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9
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-
8
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
81061
Tjernshaugen
Activity of deoxyinosine-activ ...
Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Int. J. Biochem.
13
417-421
1981
-
-
-
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3
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18
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18
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
81063
Simonis
Studies on a membrane-bound nu ...
uncultured marine bacterium
Int. J. Biochem.
13
733-738
1981
-
-
-
-
-
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23
1
3
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2
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22
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23
1
3
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22
-
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-
-
-
-
-
-
-
-
-
-
-
-
81062
Tjershaugen
-
Deoxyadenosine-activated nucle ...
Rattus norvegicus
Acta Chem. Scand. B
33
384-390
1979
5
-
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2
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1
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1
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1
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1
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2
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1
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5
-
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2
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1
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1
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
81064
Delaunay
Properties of a non-specific n ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
527
425-431
1978
-
-
-
-
-
-
2
5
2
2
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2
-
-
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-
-
1
1
-
15
-
-
1
1
-
-
-
-
-
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-
-
-
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-
-
-
-
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2
-
5
2
2
-
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-
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-
1
1
-
15
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
81065
Arsenis
An acid nucleotidase from rat ...
Rattus norvegicus
Methods Enzymol.
51
271-275
1978
-
-
-
-
-
-
8
3
2
-
-
-
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2
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-
1
-
-
2
1
-
6
-
1
-
-
-
1
1
-
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-
-
-
-
-
-
-
-
-
-
-
8
-
3
2
-
-
-
-
-
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1
-
2
1
-
6
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
81066
Tjernshaugen
Partial purification and prope ...
Rattus norvegicus
Biochem. J.
169
597-605
1978
-
-
-
-
-
-
3
15
1
-
1
-
-
2
-
-
1
-
-
2
1
1
32
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
15
1
-
1
-
-
-
-
1
-
2
1
1
32
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
81067
Schrader
Membrane-bound nucleotidase of ...
Bacillus cereus
J. Bacteriol.
133
576-583
1978
-
-
-
-
-
-
-
-
1
1
1
-
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3
-
-
1
-
-
-
1
-
15
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
1
-
-
1
-
15
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
81068
Tjernshaugen
Subcellular distribution and a ...
Rattus norvegicus
Biochem. J.
154
77-80
1976
-
-
-
-
-
-
-
-
1
-
-
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2
-
-
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-
-
16
-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
16
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
81069
Fritzson
Kinetic analysis of a rat-live ...
Rattus norvegicus
Eur. J. Biochem.
38
408-415
1973
11
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
81070
Fritzson
Regulation of rat-liver nucleo ...
Rattus norvegicus
Eur. J. Biochem.
27
38-42
1972
3
-
-
-
-
-
-
-
1
-
-
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1
-
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
81071
Fritzson
A new nucleotidase of rat live ...
Rattus norvegicus
Biochim. Biophys. Acta
235
128-141
1971
-
-
-
-
-
1
-
7
1
-
1
-
-
2
-
-
1
-
-
2
2
1
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
7
1
-
1
-
-
-
-
1
-
2
2
1
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
81072
Arsenis
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
243
5702-5708
1968
-
-
-
-
-
-
3
-
2
1
1
-
-
2
-
-
1
-
-
2
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
1
1
-
-
-
-
1
-
2
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-