Cloned (Comment) | Organism |
---|---|
orf19.3727 or gene PHO112, DNA and amino acid sequence determination and analysis | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of gene disruption null mutants of orf19.3727 of both chromosomal copies by PCR-based gene targeting method, PCR using gene-specific primers and plasmids pFA-ARG4 or pFA-HIS1. The ura3 auxotrophy in the null mutants was recovered by integrating plasmid CIp10 (carries URA3) into the RPS10 locus. Candida albicans orf19.3727 reintegrants are created by transforming full-length orf19.3727 into the null mutants. Phenotypes, overview | Candida albicans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Candida albicans | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | A0A1D8PS71 | - |
- |
Candida albicans ATCC MYA-2876 | A0A1D8PS71 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
orf19.3727 | locus name | Candida albicans |
PHO112 | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of Candida albicans orf19.3727 leads to decreased phytase activity, reduced ability to form hyphae, attenuated in vitro adhesion, and reduced ability to penetrate human epithelium, which are the major virulence attributes of this yeast | Candida albicans |
physiological function | the enzyme encoded by orf19.3727 of Candida albicans plays a key role in fungal pathogenesis, functional role of orf19.3727 in yeast-to-hyphal morphogenesis, adhesion, and in vitro virulence. Candida albicans orf19.3727 contributes to phytase activity and is crucial for hyphal growth, adhesion, and cellular invasion, and ultimately to its pathogenic potential | Candida albicans |