Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.25 extracted from

  • Nakatsu, F.; Messa, M.; Nandez, R.; Czapla, H.; Zou, Y.; Strittmatter, S.M.; De Camilli, P.
    Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway (2015), J. Cell Biol., 209, 85-95 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.25

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
D460N loss of activity with phosphatidylinositol 4-phosphate Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane colocalizes with 5-phosphatase OCRL on endocytic membranes including vesicles formed by clathrin-mediated endocytosis, macropinosomes, and Rab5 endosomes Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q8CDA1 isoform INPP5f
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information selctive for phosphatidylinositol 4-phosphate, no reaction with other phosphatidylinositols tested Mus musculus ?
-
 ?
phosphatidylinositol 4-phosphate + H2O
-
 Mus musculus phosphatidylinositol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
INPP5f
-
 Mus musculus
Sac2
-
 Mus musculus

General Information

General Information Comment Organism
physiological function Sac2/INPP5F interacts with 5-phosphatase OCRL which is potentiated by Rab5. Rab5 activity is required to recruit Sac2/INPP5F to endosomes Mus musculus