Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P97697 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
IMPA1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | ImpA1 is a pulmonary arterial hypertension-specific interacting partner of receptor for advanced glycation end products, RAGE. RAGE/IMPA1 form a complex in the pulmonary artery wall. A threefold increase in glucose 6-phosphate levels in lungs of pulmonary arterial hypertension rats correlates with accumulation of phosphatidylinositol (3,4,5)-trisphosphate, membrane translocation of phosphatidylinositol-3-kinase, and a threefold increase in membrane Akt levels and Akt phosphorylation | Rattus norvegicus |