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Literature summary for 3.1.3.25 extracted from

  • Rafikov, R.; McBride, M.L.; Zemskova, M.; Kurdyukov, S.; McClain, N.; Niihori, M.; Langlais, P.R.; Rafikova, O.
    Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension (2019), Am. J. Physiol. Lung Cell Mol. Physiol., 316, L428-L444 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97697
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-

Synonyms

Synonyms Comment Organism
IMPA1
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function ImpA1 is a pulmonary arterial hypertension-specific interacting partner of receptor for advanced glycation end products, RAGE. RAGE/IMPA1 form a complex in the pulmonary artery wall. A threefold increase in glucose 6-phosphate levels in lungs of pulmonary arterial hypertension rats correlates with accumulation of phosphatidylinositol (3,4,5)-trisphosphate, membrane translocation of phosphatidylinositol-3-kinase, and a threefold increase in membrane Akt levels and Akt phosphorylation Rattus norvegicus