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Literature summary for 3.1.3.25 extracted from

  • Murry, R.; Kniemeyer, O.; Krause, K.; Saiardi, A.; Kothe, E.
    Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune (2019), Adv. Biol. Regul., 72, S2212 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Li+ presence of lithium reduces IMPase activity by 20% and 60% in the wild type and in the constitutively active Ras1 mutant, respectively Schizophyllum commune

Organism

Organism UniProt Comment Textmining
Schizophyllum commune
-
-
-

Synonyms

Synonyms Comment Organism
Imp1
-
 Schizophyllum commune

Expression

Organism Comment Expression
Schizophyllum commune Ras1 activation in the ras1G12V mutant dramatically represses Imp1 expression down

General Information

General Information Comment Organism
physiological function presence of a crosstalk between Ras signaling and inositol phosphate signaling by inositol monophosphatase. Constitutively active Ras1 leads to the repression of IMPase transcription and lithium inhibition of IMPase activity is compensated by the induction of IMPase at transcriptome level. Presence of lithium induces a considerable shift to inositol phosphate metabolism leading to a massive increase in the level of higher phosphorylated inositol species up to the inositol pyrophosphates Schizophyllum commune