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Literature summary for 3.1.3.25 extracted from

  • Movahedzadeh, F.; Wheeler, P.R.; Dinadayala, P.; Av-Gay, Y.; Parish, T.; Daffe, M.; Stoker, N.G.
    Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis (2010), BMC Microbiol., 10, 50.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.25

Cloned(Commentary)

Cloned (Comment) Organism
genes impA and impC, genetic analysis of the four IMPase homologues that are present in the Mycobacterium tuberculosis genome, real-time quantitative PCR expression analysis Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
D86N site-directed mutagenesis of gene impC Mycobacterium tuberculosis
additional information construction of deletion mutants of genes impC and impA Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inositol 1-phosphate + H2O Mycobacterium tuberculosis
-
 myo-inositol + phosphate
-
 ?
inositol 1-phosphate + H2O Mycobacterium tuberculosis H37Rv, ATCC 25618
-
 myo-inositol + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
 genes impA or Rv1604, and impC or Rv3137
-
Mycobacterium tuberculosis H37Rv, ATCC 25618
-
 genes impA or Rv1604, and impC or Rv3137
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis myo-inositol + phosphate
-
 ?
inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis H37Rv, ATCC 25618 myo-inositol + phosphate
-
 ?
myo-inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis myo-inositol + phosphate
-
 ?
myo-inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis H37Rv, ATCC 25618 myo-inositol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
IMPase
-
 Mycobacterium tuberculosis
inositol monophosphate phosphatase
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan, lipomannan, and phosphatidylinosotol mannosides in the cell envelope, and for the production of mycothiol, which maintains the redox balance of the cell. The protein encoded by gene impA is partly responsible for inositol synthesis, while the impC encoded protein is essential, overview Mycobacterium tuberculosis