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Literature summary for 3.1.3.25 extracted from

  • Brown, A.K.; Meng, G.; Ghadbane, H.; Scott, D.J.; Dover, L.G.; Nigou, J.; Besra, G.S.; Fuetterer, K.
    Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+ (2007), BMC Struct. Biol., 7, 55.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method with in 10-14% (v/v) 2-methyl-2,4-pentanediol, 0.1 M tri-sodium citrate, pH 5.6, and 0.2 M ammonium acetate Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
Li+ inhibitory, but can amplify the effect of Mg2+ Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Li+ activates only in the presence of Mg2+ Mycobacterium tuberculosis
Mg2+ activator Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30508
-
 1 * 30508, analytical ultracentrifugation, SuhB is predominantly monomeric in the absence of the physiological activator Mg2+ Mycobacterium tuberculosis
30508
-
 2 * 30508, analytical ultracentrifugation, dimer in the presence of Mg2+ and in the crystal Mycobacterium tuberculosis
30510
-
 analytical ultracentrifugation Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sephacryl S200-HR gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerol 2-phosphate + H2O
-
 Mycobacterium tuberculosis glycerol + phosphate
-
 ?
L-myo-inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis L-myo-inositol + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 30508, analytical ultracentrifugation, dimer in the presence of Mg2+ and in the crystal Mycobacterium tuberculosis
monomer 1 * 30508, analytical ultracentrifugation, SuhB is predominantly monomeric in the absence of the physiological activator Mg2+ Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
IMPase
-
 Mycobacterium tuberculosis
inositol monophosphatase
-
 Mycobacterium tuberculosis
myo-inositol-1-phosphate phosphohydrolase
-
 Mycobacterium tuberculosis
SuhB
-
 Mycobacterium tuberculosis