Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-(1R,2R,4R,6R)-2,4,6-trihydroxycyclohexyl 1-methylphosphonate | IC50 is 260 mM | Bos taurus | |
(-)-(1R,2R,4R,6R)-6-propyloxy-2,4-dihydroxycyclohexyl 1-ethylphosphonate | competitive inhibition | Bos taurus | |
(-)-(1R,2R,4R,6R)-6-propyloxy-2,4-dihydroxycyclohexyl 1-methylphosphonate | competitive inhibition | Bos taurus | |
(-)-(1S,2R,4R,6R)-6-propyloxycyclohexane-1,2,4-triol | IC50 is about 150 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-(2-aminoethyloxy)cyclohexane-1,2,4-triol | IC50 is 5 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-(2-phenylethyl)amino-2,4-dihydroxycyclohexyl 1-methylphosphonate | IC50 is above 54 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-(2-phenylethyl)aminocyclohexane-1,2,4-triol | IC50 is 6 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-(3-aminopropyloxy)cyclohexane-1,2,4-triol | IC50 is 10 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-(4-phenylbutyl)aminocyclohexane-1,2,4-triol | non-competitive inhibition | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-aminocyclohexane-1,2,4-triol | IC50 is above 50 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-butylaminocyclohexane-1,2,4-triol | non-competitive inhibition in absence of phosphate | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-ethylaminocyclohexane-1,2,4-triol | IC50 is above 50 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-hexylamino-2,4-dihydroxycyclohexyl 1-methylphosphonate | IC50 is 1.3 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-hexylaminocyclohexane-1,2,4-triol | uncompetitive inhibition | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-hexyloxycyclohexane-1,2,4-triol | IC50 is about 10 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-methylamino-2,4-dihydroxycyclohexyl 1-methylphosphonate | IC50 is above 8 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-octylaminocyclohexane-1,2,4-triol | IC50 is 4 mM | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-[4-(2-hydroxyphenyloxy)butyloxy]cyclohexane-1,2,4-triol | competitive inhibition | Bos taurus | |
(-)-(1S,2R,4S,6R)-6-[N-(4-phenylbutyl)-N-(2-aminoethyl)-amino]cyclohexane-1,2,4-triol [hydrochloride salt] | IC50 is 9 mM | Bos taurus | |
Li+ | - |
Bos taurus | |
additional information | potency and structural features of product-like inhibitors, inhibitory mechanism, overview | Bos taurus | |
myo-inositol | non-competitive inhibition | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
(-)-(1R,2R,4R,6R)-2,4,6-trihydroxycyclohexyl-1-hydroxyphosphonate cyclohexylammonium salt | pH 8.0, 25°C | Bos taurus | |
0.1 | - |
D-myo-Inositol 1-phosphate | pH 8.0, 25°C | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required, 2 Mg2+ per active site, involved in catalysis | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
myo-inositol phosphate + H2O = myo-inositol + phosphate | catalytic mechanism and substrate-enzyme interactions, active site residues | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
commercial preparation | from brain | Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
different assay methods, overview | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(-)-(1R,2R,4R,6R)-2,4,6-trihydroxycyclohexyl cyclohexylammonium 1-hydroxyphosphonate + H2O | - |
Bos taurus | ? | - |
? | |
(-)-(1R,2R,4R,6R)-2,4,6-trihydroxycyclohexyl-1-hydroxyphosphonate cyclohexylammonium salt + H2O | - |
Bos taurus | ? | - |
? | |
D-myo-inositol 1-phosphate + H2O | catalytic mechanism and substrate-enzyme interactions | Bos taurus | D-myo-inositol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPase | - |
Bos taurus |
myo-inositol-phosphatase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
(-)-(1R,2R,4R,6R)-6-propyloxy-2,4-dihydroxycyclohexyl 1-methylphosphonate | pH 8.0, 25°C | Bos taurus | |
0.16 | - |
(-)-(1R,2R,4R,6R)-6-propyloxy-2,4-dihydroxycyclohexyl 1-ethylphosphonate | pH 8.0, 25°C | Bos taurus | |
0.3 | - |
(-)-(1S,2R,4S,6R)-6-hexylaminocyclohexane-1,2,4-triol | pH 8.0, 25°C | Bos taurus | |
0.3 | - |
(-)-(1S,2R,4S,6R)-6-butylaminocyclohexane-1,2,4-triol | pH 8.0, 25°C | Bos taurus | |
4 | - |
(-)-(1S,2R,4S,6R)-6-[4-(2-hydroxyphenyloxy)butyloxy]cyclohexane-1,2,4-triol | pH 8.0, 25°C | Bos taurus | |
9 | - |
(-)-(1S,2R,4S,6R)-6-(4-phenylbutyl)aminocyclohexane-1,2,4-triol | pH 8.0, 25°C | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1.3 | - |
IC50 is 1.3 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-hexylamino-2,4-dihydroxycyclohexyl 1-methylphosphonate | |
4 | - |
IC50 is 4 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-octylaminocyclohexane-1,2,4-triol | |
5 | - |
IC50 is 5 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-(2-aminoethyloxy)cyclohexane-1,2,4-triol | |
6 | - |
IC50 is 6 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-(2-phenylethyl)aminocyclohexane-1,2,4-triol | |
8 | - |
IC50 is above 8 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-methylamino-2,4-dihydroxycyclohexyl 1-methylphosphonate | |
9 | - |
IC50 is 9 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-[N-(4-phenylbutyl)-N-(2-aminoethyl)-amino]cyclohexane-1,2,4-triol [hydrochloride salt] | |
10 | - |
IC50 is 10 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-(3-aminopropyloxy)cyclohexane-1,2,4-triol | |
10 | - |
IC50 is about 10 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-hexyloxycyclohexane-1,2,4-triol | |
50 | - |
IC50 is above 50 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-aminocyclohexane-1,2,4-triol | |
50 | - |
IC50 is above 50 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-ethylaminocyclohexane-1,2,4-triol | |
54 | - |
IC50 is above 54 mM | Bos taurus | (-)-(1S,2R,4S,6R)-6-(2-phenylethyl)amino-2,4-dihydroxycyclohexyl 1-methylphosphonate | |
150 | - |
IC50 is about 150 mM | Bos taurus | (-)-(1S,2R,4R,6R)-6-propyloxycyclohexane-1,2,4-triol | |
260 | - |
IC50 is 260 mM | Bos taurus | (-)-(1R,2R,4R,6R)-2,4,6-trihydroxycyclohexyl 1-methylphosphonate |