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Literature summary for 3.1.3.25 extracted from

  • Kim, D.W.; Hong, J.W.; Eum, W.S.; Choi, H.S.; Choi, S.H.; Kim, S.Y.; Lee, B.R.; An, J.J.; Lee, S.H.; Lee, S.R.; Kwon, O.S.; Kwon, H.Y.; Cho, S.W.; Lee, K.S.; Park, J.; Choi, S.Y.
    Inactivation of brain myo-inositol monophosphate phosphatase by pyridoxal-5'-phosphate (2005), J. Biochem. Mol. Biol., 38, 58-64.
    View publication on PubMed
Search for more literature for 3.1.3.25

Inhibitors

Inhibitors Comment Organism Structure
pyridoxal-5'-phosphate inactivates the enzyme by covalent binding to the lysine residue of a specific binding site LQVSQQEDITK at or near the substrate binding site, the substrate D-myo-inositol 1-phosphate protects against the inactivation Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa key enzyme in the phosphoinositide cell-signaling system ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from brain Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.7
-
 purified enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phosphoglycerol + H2O
-
 Sus scrofa glycerol + phosphate
-
 ?
D-myo-inositol 1-phosphate + H2O
-
 Sus scrofa D-myo-inositol + phosphate
-
 ?
additional information key enzyme in the phosphoinositide cell-signaling system Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
IMPP
-
 Sus scrofa
myo-inositol monophosphate phosphatase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Sus scrofa