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Literature summary for 3.1.3.2 extracted from

  • Hussein, W.; Feder, D.; Schenk, G.; Guddat, L.; McGeary, R.
    Synthesis and evaluation of novel purple acid phosphatase inhibitors (2019), MedChemComm, 10, 61-71 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.2

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
1-benzyl-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa
1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Phaseolus vulgaris
1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Phaseolus vulgaris
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
CM-cellulose column chromatography and Sephadex S-300 gel filtration Phaseolus vulgaris
CM-cellulose column chromatography and Sephadex S-300 gel filtration Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Phaseolus vulgaris 4-nitrophenol + phosphate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Sus scrofa 4-nitrophenol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PAP
-
 Phaseolus vulgaris
PAP
-
 Sus scrofa
purple acid phosphatase
-
 Phaseolus vulgaris
purple acid phosphatase
-
 Sus scrofa
tartrate-resistant acid phosphatase
-
 Phaseolus vulgaris
tartrate-resistant acid phosphatase
-
 Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.013
-
 1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
0.023
-
 1-benzyl-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
0.048
-
 1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
0.076
-
 1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
0.184
-
 1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
0.276
-
 1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Sus scrofa
0.438
-
 1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
0.951
-
 1-[(4-methylphenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
0.963
-
 1-benzyl-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
1.073
-
 1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris
2.276
-
 1-[(naphthalen-1-yl)methyl]-1H-1,2,3-triazole-4-carboxylic acid at pH 4.9 and 25°C Phaseolus vulgaris