Literature summary for 3.1.3.2 extracted from

Chuang, T.D.; Chen, S.J.; Lin, F.F.; Veeramani, S.; Kumar, S.; Batra, S.K.; Tu, Y.; Lin, M.F.
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth (2010), J. Biol. Chem., 285, 23598-23606.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphorylated-ErbB-2 + H2O	Homo sapiens	cPAcP interacts with and dephosphorylates ErbB-2 primarily at Tyr1221/2 and hence blocks downstream signaling, leading to reduced cell growth	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphorylated-ErbB-2 + H2O	cPAcP interacts with and dephosphorylates ErbB-2 primarily at Tyr1221/2 and hence blocks downstream signaling, leading to reduced cell growth	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cPAcP	-	Homo sapiens
human prostatic acid phosphatase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	expression of wild type cPAcP by cDNA in cPAcP-null LNCaP C-81 cells results in decreased tyrosine phosphorylation of ErbB-2. Phosphorylation of p52Shc, proliferating cell nuclear antigen expression, and cell growth are decreased in these cells. Decreased cPAcP expression by short hairpin RNA in LNCaP C-33 cells is associated with elevated phosphorylation of ErbB-2. Its downstream p52Shc, ERK1/2, Akt, Src, STAT-3, and STAT-5 are activated, and cell proliferation, proliferating cell nuclear antigen, and cyclin D1 expression are increased	Homo sapiens

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Release 2023.1 (January 2023)