Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fostriecin | more selective inhibitor of PP2A | Homo sapiens | |
okadaic acid | specific inhibitor of PP2A | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoprotein + H2O | Homo sapiens | - |
protein + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Homo sapiens | - |
human lung microvascular endothelial cell | - |
Homo sapiens | - |
pulmonary artery endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoprotein + H2O | - |
Homo sapiens | protein + phosphate | - |
? | |
phosphorylated beta-catenin + H2O | - |
Homo sapiens | beta-catenin + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP2A | - |
Homo sapiens |
protein phosphatase 2A | - |
Homo sapiens |
Ser/Thr protein phosphatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of protein phosphatase 2A results in changes in the organization of endothelial cell cytoskeleton as microtubule dissolution and actin re-arrangement are detected. Depletion of Balpha regulatory subunit of protein phosphatase 2A has similar effect on the cytoskeleton structure of the cells | Homo sapiens |
physiological function | the enzyme plays a significant role in the maintenance of endothelial cell cytoskeleton and barrier function with special focus on the Balpha (regulatory) subunit of protein phosphatase 2A. The PP2A Balpha regulatory subunit associates with adherent junction proteins | Homo sapiens |