Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of key residues within the hydrophobic docking-cleft of the calcineurin catalytic domain impairs binding to all human RCAN proteins and to the calcineurin interacting proteins Cabin1 and AKAP79, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RCAN proteins | RCAN inhibition of CN phosphatase activity is mediated by the extreme C-terminal region | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | physical and functional interaction of the phosphatase calcineurin with a group of modulators, the RCAN protein family, e.g. proteins Cabin1 and AKAP79, a valine-rich region within the RCAN carboxyl region is essential for binding to the docking site in calcineurin, overview. Competition by substrates and modulators for a common docking site appears to be an essential mechanism in the regulation of Ca2+-calcineurin signaling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | physical and functional interaction of the phosphatase calcineurin with a group of modulators, the RCAN protein family, e.g. proteins Cabin1 and AKAP79, a valine-rich region within the RCAN carboxyl region is essential for binding to the docking site in calcineurin, overview. Competition by substrates and modulators for a common docking site appears to be an essential mechanism in the regulation of Ca2+-calcineurin signaling | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the CnA hydrophobic cleft, containing the NIR site, defines a common docking site for CN regulators, motifs involved in calcineurin inetractions with RCAN proteins, overview. The CnA beta-strand 14 is required for binding to the RCAN EV-motif. The EV-motif blocks CN/NFAT signaling but does not inhibit calcineurin phosphatase activity | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
calcineurin | - |
Homo sapiens |
CN phosphatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Ca2+-calcineurin signaling | Homo sapiens |