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Literature summary for 3.1.3.16 extracted from

  • Lee, S.U.; Song, H.O.; Lee, W.; Singaravelu, G.; Yu, J.R.; Park, W.Y.
    Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans (2009), Mol. Cells, 28, 455-461.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin calcineurin is a Ca2+/calmodulin-activated Ser/Thr phosphatase Caenorhabditis elegans

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of cacineurin with HLH-11 and interaction analysis using the yeast two-hybrid system Caenorhabditis elegans

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcineurin is a Ca2+/calmodulin-activated Ser/Thr phosphatase Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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subunits A and B are encoded by genes tax-6 and cnb-1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HLH-11, a member of basic helix-loop-helix proteins, binds to calcineurin catalytic subunit Tax-6, probably regulating TAX-6 as a transcription factor and/or a functional regulator. HLH-11 is involved in regulation of many developmental processes such as cell proliferation and differentiation, sex determination and myogenesis, HLH-11 deletion phenotype, overview Caenorhabditis elegans ?
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Subunits

Subunits Comment Organism
heterodimer
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Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
calcineurin
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Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function calcineurin play roles in various signaling pathways such as fertility, movement, body size regulation and serotonin-mediated egg laying Caenorhabditis elegans