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Literature summary for 3.1.3.16 extracted from

  • Tumlin, J.A.; Roberts, B.R.; Kokko, K.E.; El Minshawy, O.; Gooch, J.L.
    T-cell receptor-stimulated calcineurin activity is inhibited in isolated T cells from transplant patients (2009), J. Pharmacol. Exp. Ther., 330, 602-607.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is stimulated by the T-cell receptor Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A
-
 Homo sapiens
tacrolimus 27-30% inhibition at 5 ng/ml, females and males Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity is much higher in mlaes compared to females, overview Homo sapiens
0.0000008 0.0000017 T-cells from females and males, not stimulated and T-cell-stimulated Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a phosphoprotein + H2O
-
 Homo sapiens dephosphorylated protein + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
calcineurin
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens