Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclosporin A | an immunosuppressive drug. 25% inhibition in keratinocytes at 831 nM, 49% in melanocytes | Homo sapiens | |
EGTA | - |
Homo sapiens | |
additional information | calcineurin inhibition in fibroblasts and keratinocytes may be of influence on the overall functioning of the skin immune system. No inhibition of calcineurin by okadaic acid | Homo sapiens | |
pimecrolimus | an immunosuppressive drug | Homo sapiens | |
tacrolimus | an immunosuppressive drug. 89% inhibition in keratinocytes at 124 nM, 74% in fibroblasts, and 75% in melanocytes | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcium-dependent protein phosphatase 2B | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
fibroblast cell line | F0502 cell | Homo sapiens | - |
fibroblast cell line | F0503 cell | Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
melanocyte | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0038 | 0.0077 | keratinoyctes | Homo sapiens |
0.0085 | 0.0127 | fibroblasts | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
calcineurin | - |
Homo sapiens |
calcium-dependent protein phosphatase 2B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000004 | 0.0000013 | in fibroblasts | Homo sapiens | tacrolimus | |
0.000002 | 0.0000027 | in fibroblasts | Homo sapiens | cyclosporin A | |
0.000006 | 0.0000201 | in fibroblasts | Homo sapiens | pimecrolimus |
General Information | Comment | Organism |
---|---|---|
malfunction | calcineurin inhibition in fibroblasts and keratinocytes may be of influence on the overall functioning of the skin immune system | Homo sapiens |