Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calyculin A | inhibitor of isozymes PP1 and PP2A | Homo sapiens | |
Inhibitor-1 | inhibitor of isozyme PP1 | Homo sapiens | |
Inhibitor-2 | inhibitor of isozyme PP1 | Homo sapiens | |
microcystin-LR | inhibitor of isozymes PP1 and PP2A | Homo sapiens | |
additional information | isozyme PP2 is insensitive to inhibitor-1 and inhibitor-2 | Homo sapiens | |
okadaic acid | inhibitor of isozymes PP1 and PP2A | Homo sapiens | |
tautomycin | inhibitor of isozymes PP1 and PP2A | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | isozyme PP2B is dependent on Ca2+ | Homo sapiens | |
Fe2+ | isozyme PP1 contains one Fe2+ and isozyme PP2B contains one Fe2+ at the centre of the catalytic site | Homo sapiens | |
Mn2+ | isozyme PP2A contains two Mn2+ and isozyme PP1 contains one Mn2+ at the centre of the catalytic site | Homo sapiens | |
Zn2+ | isozyme PP2B contains one Zn2+ at the centre of the catalytic site | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated phosphorylase kinase + H2O | Homo sapiens | isozyme PP1 preferentially dephosphorylates the beta-subunit of phosphorylase kinase, isozyme PP2 preferentially dephosphorylates the alpha-subunit of phosphorylase kinase | phosphorylase kinase + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoprotein + H2O | - |
Homo sapiens | protein + phosphate | - |
? | |
phosphorylated phosphorylase kinase + H2O | isozyme PP1 preferentially dephosphorylates the beta-subunit of phosphorylase kinase, isozyme PP2 preferentially dephosphorylates the alpha-subunit of phosphorylase kinase | Homo sapiens | phosphorylase kinase + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | isozyme PP1 and isozyme PP2B | Homo sapiens |
heterotrimer | the PP2A holoenzyme consists of a heterodimeric core enzyme, comprising a scaffolding subunit and a catalytic subunit, as well as a variable regulatory subunit | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PP1 | - |
Homo sapiens |
PP2A | - |
Homo sapiens |
PP2B | also known as calcineurin | Homo sapiens |
type-I phosphatase | - |
Homo sapiens |
type-II phosphatase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | isozyme PP2B is dependent on calmodulin | Homo sapiens |