Literature summary for 3.1.3.16 extracted from

Zhao, J.; Wu, H.W.; Chen, Y.J.; Tian, H.P.; Li, L.X.; Han, X.; Guo, J.
Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2+/CaM-dependent ERK activation in cerebral ischemia (2008), J. Neurosci. Res., 86, 2733-2745.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ceramide	ceramide induces increase of PP2A activity	Rattus norvegicus

Application

Application	Comment	Organism
medicine	PP2A inhibition may offer a new therapeutic approach to the treatment of diseases caused by cerebral ischemia	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
cantharidin	-	Rattus norvegicus
okadaic acid	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphorylated extracellular-signal-regulated kinase + H2O	PP2A is involved in the inactivation, but not the activation, of extracellular-signal-regulated kinase	Rattus norvegicus	extracellular-signal-regulated kinase + phosphate	-	?
phosphorylated Raf + H2O	Raf is dephosphorylated at Ser259	Rattus norvegicus	Raf + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PP2A	-	Rattus norvegicus
protein phosphatase 2A	-	Rattus norvegicus

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Release 2023.1 (January 2023)