Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ERK-2 | association with ERK-2 results in catalytic activation of Pac-1 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | MKP-1 inhibitors may have a use in cancer therapy | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | MKP-1 is predominantly nuclear | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95248 | - |
- |
Homo sapiens | O95278 | - |
- |
Homo sapiens | P28562 | - |
- |
Homo sapiens | P60484 | - |
- |
Homo sapiens | Q05923 | - |
- |
Homo sapiens | Q16828 | - |
- |
Homo sapiens | Q93096 | - |
- |
Homo sapiens | Q9BV47 | - |
- |
Homo sapiens | Q9Y6W6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | - |
Homo sapiens | - |
eosinophil | - |
Homo sapiens | - |
hematopoietic cell | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
mast cell | umbilical cord derived mast cell | Homo sapiens | - |
neuroblastoma cell | MKP-8 is highly expressed in neuroblastoma | Homo sapiens | - |
neuroepithelioma cell | MKP-8 is highly expressed in neuroepithelioma | Homo sapiens | - |
polymorphonuclear cell | - |
Homo sapiens | - |
retinoblastoma cell | MKP-8 is highly expressed in retinoblastoma | Homo sapiens | - |
Th1-cell | - |
Homo sapiens | - |
Th2-cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | laforin shows diminished in vitro dephosphorylation of p-nitrophenyl phosphate in the presence of glucose polymers | Homo sapiens | ? | - |
? | |
additional information | malin is an E3 ubiquitin ligase that promotes the degradation of laforin | Homo sapiens | ? | - |
? | |
additional information | MKP-5 does not dephosphorylate ERK | Homo sapiens | ? | - |
? | |
phosphatidylinositol-(3,4,5)-triphosphate + H2O | the enzyme displays activity towards the D3 position of the phosphoinositide second messenger phosphatidylinositol (3,4,5)-triphosphate | Homo sapiens | ? | - |
? | |
phosphorylated c-Jun N-terminal kinase + H2O | - |
Homo sapiens | c-Jun N-terminal kinase + phosphate | - |
? | |
phosphorylated ERK + H2O | - |
Homo sapiens | ERK + phosphate | - |
? | |
phosphorylated ERK + H2O | binds heat shock transcription factor 4 in a complex with ERK, controlling transcription factor DNA binding | Homo sapiens | ERK + phosphate | - |
? | |
phosphorylated ERK-2 + H2O | - |
Homo sapiens | ERK-2 + phosphate | - |
? | |
phosphorylated ERK-2 + H2O | preferred substrate | Homo sapiens | ERK-2 + phosphate | - |
? | |
phosphorylated GSK3beta + H2O | laforin dephosphorylates the inhibitory Ser9 of GSK3beta | Homo sapiens | GSK3beta + phosphate | - |
? | |
phosphorylated p38 + H2O | - |
Homo sapiens | p38 + phosphate | - |
? | |
phosphorylated protein kinase CK2alpha + H2O | - |
Homo sapiens | protein kinase CK2alpha + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class I cysteine-based dual-specificity phosphatase | cf. EC 3.1.3.48 | Homo sapiens |
class I cysteine-based dual-specificity phosphatase | cf. EC 3.1.3.48 and EC 3.1.3.67 | Homo sapiens |
DSP | PTP domain class I DSPs differ from classical PTPs in that they can dephosphorylate phospho-Tyr, phospho-Ser and phospho-Thr residues, as well as nonproteinaceous substrates | Homo sapiens |
dual specificity protein phosphatase 1 | - |
Homo sapiens |
dual specificity protein phosphatase 10 | - |
Homo sapiens |
dual specificity protein phosphatase 26 | - |
Homo sapiens |
dual specificity protein phosphatase 6 | - |
Homo sapiens |
DUSP1 | - |
Homo sapiens |
DUSP10 | - |
Homo sapiens |
DUSP26 | - |
Homo sapiens |
DUSP6 | - |
Homo sapiens |
EPM2A | - |
Homo sapiens |
laforin | - |
Homo sapiens |
MKP-1 | - |
Homo sapiens |
MKP-5 | - |
Homo sapiens |
MKP-8 | - |
Homo sapiens |
MMAC-1 | - |
Homo sapiens |
MTMR5 | - |
Homo sapiens |
Pac-1 | - |
Homo sapiens |
phosphatase of activated cells 1 | - |
Homo sapiens |
phosphatase of regenerating liver | - |
Homo sapiens |
PRL-1 | - |
Homo sapiens |
PTEN | - |
Homo sapiens |
PTP | - |
Homo sapiens |
PTPCAAX1 | - |
Homo sapiens |
SBF1 | - |
Homo sapiens |
Set-binding factor 1 | - |
Homo sapiens |
TEP1 | - |
Homo sapiens |