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Literature summary for 3.1.3.16 extracted from

  • Eichhorn, P.J.; Creyghton, M.P.; Bernards, R.
    Protein phosphatase 2A regulatory subunits and cancer (2009), Biochim. Biophys. Acta, 1795, 1-15.
    View publication on PubMed
Search for more literature for 3.1.3.16

Activating Compound

Activating Compound Comment Organism Structure
PTPase activator PTPase activator acts like a chaperone directly affecting the activity of PP2Ac Homo sapiens

Application

Application Comment Organism
medicine PP2A acts as a tumor suppressor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated Akt protein + H2O
-
 Homo sapiens Akt protein + phosphate the dephosphorylation leads to inhibition of Akt protein ?
phosphorylated androgen receptor + H2O
-
 Homo sapiens androgen receptor + phosphate the dephosphorylation leads to inhibition of androgen receptor ?
phosphorylated AP-1/AP-2 + H2O
-
 Homo sapiens AP-1/AP-2 + phosphate the dephosphorylation leads to inhibition of AP-1/AP-2 ?
phosphorylated APC protein + H2O
-
 Homo sapiens APC protein + phosphate the dephosphorylation leads to inhibition of APC protein ?
phosphorylated ATM protein + H2O
-
 Homo sapiens ATM protein + phosphate the dephosphorylation leads to inhibition of ATM protein ?
phosphorylated aurora A + H2O
-
 Homo sapiens aurora A + phosphate the dephosphorylation leads to inhibition of aurora A ?
phosphorylated axin + H2O
-
 Homo sapiens axin + phosphate the dephosphorylation leads to inhibition of axin ?
phosphorylated B-catenin + H2O
-
 Homo sapiens B-catenin + phosphate the dephosphorylation leads to activation of B-catenin ?
phosphorylated BAD protein + H2O
-
 Homo sapiens BAD protein + phosphate the dephosphorylation leads to activation of BAD protein ?
phosphorylated BAX protein + H2O
-
 Homo sapiens BAX protein + phosphate the dephosphorylation leads to activation of BAX protein ?
phosphorylated BCL-2 + H2O
-
 Homo sapiens BCL-2 + phosphate the dephosphorylation leads to inhibition of BCL-2 ?
phosphorylated c-MET + H2O
-
 Homo sapiens c-MET + phosphate the dephosphorylation leads to inhibition of c-MET ?
phosphorylated c-Myc + H2O
-
 Homo sapiens c-Myc + phosphate the dephosphorylation leads to inhibition of c-Myc ?
phosphorylated calpain + H2O
-
 Homo sapiens calpain + phosphate the dephosphorylation leads to inhibition of calpain ?
phosphorylated CAM kinase IV + H2O
-
 Homo sapiens CAM kinase IV + phosphate the dephosphorylation leads to inhibition of CAM kinase IV ?
phosphorylated carboxypeptidase D + H2O
-
 Homo sapiens carboxypeptidase D + phosphate the dephosphorylation leads to inhibition of carboxypeptidase D ?
phosphorylated CAS protein + H2O
-
 Homo sapiens CAS protein + phosphate the dephosphorylation leads to inhibition of CAS protein ?
phosphorylated Cav1.2 + H2O
-
 Homo sapiens Cav1.2 + phosphate the dephosphorylation leads to inhibition of Cav1.2 ?
phosphorylated Cdc25c + H2O
-
 Homo sapiens Cdc25c + phosphate the dephosphorylation leads to inhibition of Cdc25c ?
phosphorylated Cdc6 protein + H2O
-
 Homo sapiens Cdc6 protein + phosphate the dephosphorylation leads to activation of Cdc6 protein ?
phosphorylated CFTRCXCR2 + H2O
-
 Homo sapiens CFTRCXCR2 + phosphate the dephosphorylation leads to inhibition of CFTRCXCR2 ?
phosphorylated Chk1 protein + H2O
-
 Homo sapiens Chk1 protein + phosphate the dephosphorylation leads to inhibition of Chk1 protein ?
phosphorylated Chk2 + H2O
-
 Homo sapiens Chk2 + phosphate the dephosphorylation leads to inhibition of Chk2 ?
phosphorylated DARPP-32 + H2O
-
 Homo sapiens DARP-32 + phosphate the dephosphorylation leads to inhibition of DARP-32 ?
phosphorylated E-cadherin + H2O
-
 Homo sapiens E-cadherin + phosphate the dephosphorylation leads to activation of E-cadherin ?
phosphorylated ERK protein + H2O
-
 Homo sapiens ERK protein + phosphate the dephosphorylation leads to inhibition of ERK protein ?
phosphorylated estrogen receptor A + H2O
-
 Homo sapiens estrogen receptor A + phosphate the dephosphorylation leads to inhibition of estrogen receptor A ?
phosphorylated Gp130 protein + H2O
-
 Homo sapiens Gp130 protein + phosphate the dephosphorylation leads to activation of Gp130 protein ?
phosphorylated H2AX + H2O
-
 Homo sapiens H2AX + phosphate the dephosphorylation leads to inhibition of H2AX ?
phosphorylated HAND-1 + H2O
-
 Homo sapiens HAND-1 + phosphate the dephosphorylation leads to inhibition of HAND-1 ?
phosphorylated HAND-2 + H2O
-
 Homo sapiens HAND-2 + phosphate the dephosphorylation leads to inhibition of HAND-2 ?
phosphorylated HDAC4 + H2O
-
 Homo sapiens HDAC4 + phosphate the dephosphorylation leads to inhibition of HDAC4 ?
phosphorylated IKKB + H2O
-
 Homo sapiens IKKB + phosphate the dephosphorylation leads to inhibition of IKKB ?
phosphorylated IKKB protein + H2O
-
 Homo sapiens IKKB protein + phosphate the dephosphorylation leads to activation of IKKB protein ?
phosphorylated JNK protein + H2O
-
 Homo sapiens JNK protein + phosphate the dephosphorylation leads to inhibition of JNK protein ?
phosphorylated KSR protein + H2O
-
 Homo sapiens KSR protein + phosphate the dephosphorylation leads to activation of KSR protein ?
phosphorylated Mdm2 protein + H2O
-
 Homo sapiens Mdm2 protein + phosphate the dephosphorylation leads to activation of Mdm2 protein ?
phosphorylated MEK3 + H2O
-
 Homo sapiens MEK3 + phosphate the dephosphorylation leads to inhibition of MEK3 ?
phosphorylated MEKK3 + H2O
-
 Homo sapiens MEKK3 + phosphate the dephosphorylation leads to inhibition of MEKK3 ?
phosphorylated MKK4 + H2O
-
 Homo sapiens MKK4 + phosphate the dephosphorylation leads to inhibition of MKK4 ?
phosphorylated nemo protein + H2O
-
 Homo sapiens nemo protein + phosphate the dephosphorylation leads to inhibition of nemo protein ?
phosphorylated occludin + H2O
-
 Homo sapiens occludin + phosphate the dephosphorylation leads to inhibition of occludin ?
phosphorylated P107 + H2O
-
 Homo sapiens P107 + phosphate the dephosphorylation leads to inhibition of P107 ?
phosphorylated p53 protein + H2O
-
 Homo sapiens p53 protein + phosphate the dephosphorylation leads to activation of p53 protein ?
phosphorylated PACS-1 + H2O
-
 Homo sapiens PACS-1 + phosphate the dephosphorylation leads to inhibition of PACS-1 ?
phosphorylated paxillin + H2O
-
 Homo sapiens paxillin + phosphate the dephosphorylation leads to inhibition of paxillin ?
phosphorylated period + H2O
-
 Homo sapiens period + phosphate the dephosphorylation leads to activation of period ?
phosphorylated PIM protein + H2O
-
 Homo sapiens PIM protein + phosphate the dephosphorylation leads to inhibition of PIM protein ?
phosphorylated PKCbeta II + H2O
-
 Homo sapiens PKBbeta II + phosphate the dephosphorylation leads to inhibition of PKCbeta II ?
phosphorylated PKCdelta + H2O
-
 Homo sapiens PKCdelta + phosphate the dephosphorylation leads to inhibition of PKCdelta ?
phosphorylated Raf1 + H2O
-
 Homo sapiens Raf1 + phosphate the dephosphorylation leads to activation of Raf1 ?
phosphorylated RalA + H2O
-
 Homo sapiens RalA + phosphate the dephosphorylation leads to inhibition of RalA ?
phosphorylated RelA + H2O
-
 Homo sapiens RelA + phosphate the dephosphorylation leads to inhibition of RelA ?
phosphorylated SCR protein + H2O
-
 Homo sapiens SCR protein + phosphate the dephosphorylation leads to inhibition of SCR protein ?
phosphorylated securin + H2O
-
 Homo sapiens securin + phosphate the dephosphorylation leads to activation of securin ?
phosphorylated seratonin + H2O
-
 Homo sapiens seratonin + phosphate the dephosphorylation leads to activation of seratonin ?
phosphorylated Shc protein + H2O
-
 Homo sapiens Shc protein + phosphate the dephosphorylation leads to inhibition of Shc protein ?
phosphorylated Sp1 + H2O
-
 Homo sapiens Sp1 + phosphate the dephosphorylation leads to activation of Sp1 ?
phosphorylated sprouty + H2O
-
 Homo sapiens sprouty + phosphate the dephosphorylation leads to activation of sprouty ?
phosphorylated Src protein + H2O
-
 Homo sapiens Src protein + phosphate the dephosphorylation leads to inhibition of Src protein ?
phosphorylated tau protein + H2O
-
 Homo sapiens tau protein + phosphate the dephosphorylation leads to activation of tau protein ?
phosphorylated TRAF2 + H2O
-
 Homo sapiens TRAF2 + phosphate the dephosphorylation leads to inhibition of TRAF2 ?
phosphorylated vimentin + H2O
-
 Homo sapiens vimentin + phosphate the dephosphorylation leads to activation of vimentin ?

Subunits

Subunits Comment Organism
heterotrimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
PP2A
-
 Homo sapiens
PP2Ac catalytic subunit of protein phosphatase 2A Homo sapiens
PR65 structural core subunit of protein phosphatase 2A Homo sapiens
protein phosphatase type 2A
-
 Homo sapiens