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Literature summary for 3.1.3.16 extracted from
- A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A (2006), Mol. Pharmacol., 69, 608-617.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| adenylyl cyclase AC8 | from Rattus norvegicus | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| PP2A, DNA and amino acid sequence determination and analysis, expression of the N-terminal Ca2+/calmodulin-binding activation domain of Rattus norvegicus adenylate cyclase and the catalytic subunits of human PP2A in a yeast two-hybrid system | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Mus musculus |  |
| Ca2+ | activates | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| forebrain | - |
Mus musculus | - |
| HEK-293 cell | - |
Homo sapiens | - |
| hippocampus | - |
Mus musculus | - |
| neuron | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | direct interaction between the N terminus of Rattus norvegicus adenylyl cyclase AC8 and the active catalytic subunit of PP2A activates the dephosphorylation activity | Mus musculus | ? | - |
? | |
| additional information | direct interaction between the N terminus of Rattus norvegicus adenylyl cyclase AC8 and the active catalytic subunit of PP2A activates the dephosphorylation activity | Homo sapiens | ? | - |
? | |
| phosphorylated myelin basic protein + H2O | - |
Mus musculus | myelin basic protein + phosphate | - |
? | |
| phosphorylated myelin basic protein + H2O | - |
Homo sapiens | myelin basic protein + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PP2A | - |
Mus musculus |
| PP2A | - |
Homo sapiens |
| protein phosphatase 2A | - |
Mus musculus |
| protein phosphatase 2A | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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