Cloned (Comment) | Organism |
---|---|
co-overexpression of HA-tagged PP2A catalytic subunit and regulatory subunit B56alpha, with c-Myc in HEK-293 cells, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inhibition of PP2A-B56alpha by specific small hairpin RNA leads to c-Myc overexpression, elevated levels of c-Myc Ser62 phosphorylation, increased c-Myc activity, and can lead to cell transformation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
small T antigen of SV40 virus | specifically inhibits PP2A holoenzymes with B55 or B56 regulatory subunits | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated c-Myc + H2O | Homo sapiens | PP2A plays an important role in control of proto-oncogene c-Myc by destabilization of c-Myc and promotion of its ubiquitin-mediated degradation, PP2a has tumor-suppressor activity, c-Myc regulation is essential for normal cell function, overview | c-Myc + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated c-Myc + H2O | PP2A plays an important role in control of proto-oncogene c-Myc by destabilization of c-Myc and promotion of its ubiquitin-mediated degradation, PP2a has tumor-suppressor activity, c-Myc regulation is essential for normal cell function, overview | Homo sapiens | c-Myc + phosphate | - |
? | |
phosphorylated c-Myc + H2O | dephosphorylation of Ser62, PP2A binds to c-Myc via targeting by regulatory subunit B56alpha, overview | Homo sapiens | c-Myc + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | regulatory subunit B56alpha forms a holoenzyme with the PP2A catalytic subunit | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
protein phosphatase 2A regulatory subunit B56alpha | - |
Homo sapiens |