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Literature summary for 3.1.3.16 extracted from

  • Takahashi, K.; Nakajima, E.; Suzuki, K.
    Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1 (2006), J. Cell. Physiol., 206, 814-820.
    View publication on PubMed
Search for more literature for 3.1.3.16

Protein Variants

Protein Variants Comment Organism
additional information HME cell treatment with siRNA for PP2A regulatory subunit A causes disruption of cell-cell adhesion and F-actin assembly without affecting the complex formation of E-cadherin with beta-and alpha-catenins, PP2A inactivation induces the dissociation of IQGAP1 from the E-cadheri-catenins complex Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid PP2A inhibition induces the dissociation of IQGAP1 from the E-cadheri-catenins complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PP2A is involved in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1, an effector of small GTPase Rac ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HME cell PP2A is localized in the cell-cell adhesion sites between adjacent cells and associated with E-cadherin-cateinins complex in healthy human mammary epithelial HME cells Homo sapiens
-
mammary gland epithelium Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP2A is involved in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1, an effector of small GTPase Rac Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PP2A
-
 Homo sapiens
protein phosphatase 2A
-
 Homo sapiens