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Literature summary for 3.1.3.16 extracted from

  • Adams, D.G.; Coffee, R.L., Jr.; Zhang, H.; Pelech, S.; Strack, S.; Wadzinski, B.E.
    Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes (2005), J. Biol. Chem., 280, 42644-42654.
    View publication on PubMed
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
tetracycline-inducible, stable overexpression of FLAG-tagged PP2A subunits in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information PP2A subunit knock-down by RNAi, effects of altered subunit Balpha/delta level on cellular phosphoprotein levels, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
okadaic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PP2A regulates a wide variety of cellular signal transduction pathways, and performs positive regulation of Raf1-MEK1/2-ERK1/2 signaling at multiple steps of the pathway, overview ?
-
 ?
phosphorylated ERK1 + H2O Homo sapiens
-
 ERK1 + phosphate
-
 ?
phosphorylated ERK2 + H2O Homo sapiens
-
 ERK2 + phosphate
-
 ?
phosphorylated Raf1 + H2O Homo sapiens
-
 Raf-1 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant FLAG-tagged PP2A subunits from HEK-293T cells by anti-FLAG immunoaffinity chromatography Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
reconstitution of PP2A holoenzymes with recombinant subunits, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP2A regulates a wide variety of cellular signal transduction pathways, and performs positive regulation of Raf1-MEK1/2-ERK1/2 signaling at multiple steps of the pathway, overview Homo sapiens ?
-
 ?
phosphorylated ERK1 + H2O
-
 Homo sapiens ERK1 + phosphate
-
 ?
phosphorylated ERK2 + H2O
-
 Homo sapiens ERK2 + phosphate
-
 ?
phosphorylated Raf1 + H2O
-
 Homo sapiens Raf-1 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP2A
-
 Homo sapiens
protein serine/threonine phosphatase 2A
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens